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DOI | 10.1038/s41467-017-01116-z |
Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38 alpha through TGF-beta and JNK signaling | |
Batlle, Raquel1; Andres, Eva1; Gonzalez, Lorena1; Llonch, Elisabet1; Igea, Ana1; Gutierrez-Prat, Nuria1; Berenguer-Llergo, Antoni1; Nebreda, Angel R.1,2 | |
2019-07-11 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain |
英文摘要 | The formation of new blood vessels is essential for normal development, tissue repair and tumor growth. Here we show that inhibition of the kinase p38 alpha enhances angiogenesis in human and mouse colon tumors. Mesenchymal cells can contribute to tumor angiogenesis by regulating proliferation and migration of endothelial cells. We show that p38 alpha negatively regulates an angiogenic program in mesenchymal stem/stromal cells (MSCs), multipotent progenitors found in perivascular locations. This program includes the acquisition of an endothelial phenotype by MSCs mediated by both TGF-beta and JNK, and negatively regulated by p38 alpha. Abrogation of p38 alpha in mesenchymal cells increases tumorigenesis, which correlates with enhanced angiogenesis. Using genetic models, we show that p38 alpha regulates the acquisition of an endothelial-like phenotype by mesenchymal cells in colon tumors and damage tissue. Taken together, our results indicate that p38 alpha in mesenchymal cells restrains a TGF-beta-induced angiogenesis program including their ability to transdifferentiate into endothelial cells. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474825100002 |
WOS关键词 | STEM-CELLS ; PHARMACOLOGICAL INHIBITION ; VASCULAR DEVELOPMENT ; KINASE TAK1 ; MAP KINASE ; GROWTH ; PROLIFERATION ; ACTIVATION ; CANCER ; MOUSE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203495 |
专题 | 资源环境科学 |
作者单位 | 1.Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain; 2.ICREA, Pg Lluis Co 23, Barcelona 08010, Spain |
推荐引用方式 GB/T 7714 | Batlle, Raquel,Andres, Eva,Gonzalez, Lorena,et al. Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38 alpha through TGF-beta and JNK signaling[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Batlle, Raquel.,Andres, Eva.,Gonzalez, Lorena.,Llonch, Elisabet.,Igea, Ana.,...&Nebreda, Angel R..(2019).Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38 alpha through TGF-beta and JNK signaling.NATURE COMMUNICATIONS,10. |
MLA | Batlle, Raquel,et al."Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38 alpha through TGF-beta and JNK signaling".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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