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DOI | 10.1038/s41467-017-00919-4 |
Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear | |
Chen, Zhaowei1; Lu, Jiankai1; Zhang, Changjie2,3; Hsia, Isaac1; Yu, Xinheng2,3; Marecki, Leo1; Marecki, Eric1; Asmani, Mohammadnabi1; Jain, Shilpa4; Neelamegham, Sriram2,3; Zhao, Ruogang1 | |
2019-05-03 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Blood clotting at the vascular injury site is a complex process that involves platelet adhesion and clot stiffening/contraction in the milieu of fluid flow. An integrated understanding of the hemodynamics and tissue mechanics regulating this process is currently lacking due to the absence of an experimental system that can simultaneously model clot formation and measure clot mechanics under shear flow. Here we develop a microfluidic-integrated microclot-array-elastometry system (clotMAT) that recapitulates dynamic changes in clot mechanics under physiological shear. Treatments with procoagulants and platelet antagonists and studies with diseased patient plasma demonstrate the ability of the system to assay clot biomechanics associated with common antiplatelet treatments and bleeding disorders. The changes of clot mechanics under biochemical treatments and shear flow demonstrate independent yet equally strong effects of these two stimulants on clot stiffening. This microtissue force sensing system may have future research and diagnostic potential for various bleeding disorders. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000466699900011 |
WOS关键词 | VON-WILLEBRAND-FACTOR ; NONLINEAR ELASTICITY ; MICROFLUIDIC DEVICES ; PLATELET-ADHESION ; BLOOD-CLOTS ; MECHANICS ; MICROTISSUES ; HEMOSTASIS ; DEPOSITION ; MANIPULATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203482 |
专题 | 资源环境科学 |
作者单位 | 1.SUNY Buffalo, Dept Biomed Engn, Buffalo, NY 14260 USA; 2.SUNY Buffalo, Dept Chem & Biol Engn, Buffalo, NY 14260 USA; 3.SUNY Buffalo, Clin & Translat Res Ctr, Buffalo, NY 14260 USA; 4.John R Oishei Childrens Hosp Buffalo, Hemophilia Ctr Western New York, Dept Pediat, Div Pediat Hematol Oncol, Buffalo, NY 14203 USA |
推荐引用方式 GB/T 7714 | Chen, Zhaowei,Lu, Jiankai,Zhang, Changjie,et al. Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Chen, Zhaowei.,Lu, Jiankai.,Zhang, Changjie.,Hsia, Isaac.,Yu, Xinheng.,...&Zhao, Ruogang.(2019).Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear.NATURE COMMUNICATIONS,10. |
MLA | Chen, Zhaowei,et al."Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear".NATURE COMMUNICATIONS 10(2019). |
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