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DOI | 10.1038/s41467-017-00923-8 |
WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis | |
Tsarouhas, Vasilios1,2; Liu, Dan1; Tsikala, Georgia1; Fedoseienko, Alina3,4; Zinn, Kai5; Matsuda, Ryo1; Billadeau, Daniel D.3,4; Samakovlis, Christos1,2,6 | |
2019-05-16 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; USA; Germany |
英文摘要 | Filamentous actin (F-actin) networks facilitate key processes like cell shape control, division, polarization and motility. The dynamic coordination of F-actin networks and its impact on cellular activities are poorly understood. We report an antagonistic relationship between endosomal F-actin assembly and cortical actin bundle integrity during Drosophila airway maturation. Double mutants lacking receptor tyrosine phosphatases (PTP) Ptp10D and Ptp4E, clear luminal proteins and disassemble apical actin bundles prematurely. These defects are counterbalanced by reduction of endosomal trafficking and by mutations affecting the tyrosine kinase Btk29A, and the actin nucleation factor WASH. Btk29A forms protein complexes with Ptp10D and WASH, and Btk29A phosphorylates WASH. This phosphorylation activates endosomal WASH function in flies and mice. In contrast, a phospho-mimetic WASH variant induces endosomal actin accumulation, premature luminal endocytosis and cortical F-actin disassembly. We conclude that PTPs and Btk29A regulate WASH activity to balance the endosomal and cortical F-actin networks during epithelial tube maturation. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000468023700002 |
WOS关键词 | RECEPTOR TYROSINE PHOSPHATASES ; CELL-SHAPE CHANGES ; FUNCTIONS DOWNSTREAM ; TUBE ELONGATION ; DROSOPHILA ; PROTEIN ; KINASE ; TRAFFICKING ; REGULATORS ; COMPLEX |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203480 |
专题 | 资源环境科学 |
作者单位 | 1.Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden; 2.SciLifeLab, SE-17165 Stockholm, Sweden; 3.Mayo Clin, Coll Med, Dept Biochem, Rochester, MN 55905 USA; 4.Mayo Clin, Coll Med, Div Oncol Res, Rochester, MN 55905 USA; 5.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA; 6.Justus Liebig Univ Giessen, Cardiopulm Inst, Aulweg 130, D-35392 Giessen, Germany |
推荐引用方式 GB/T 7714 | Tsarouhas, Vasilios,Liu, Dan,Tsikala, Georgia,et al. WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Tsarouhas, Vasilios.,Liu, Dan.,Tsikala, Georgia.,Fedoseienko, Alina.,Zinn, Kai.,...&Samakovlis, Christos.(2019).WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis.NATURE COMMUNICATIONS,10. |
MLA | Tsarouhas, Vasilios,et al."WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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