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DOI | 10.1038/s41467-017-01182-3 |
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex | |
Domanski, Aleksander P. F.1,2,3,4; Booker, Sam A.2,3,5; Wyllie, David J. A.2,3,5,6; Isaac, John T. R.4,7; Kind, Peter C.2,3,5,6 | |
2019-10-23 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Scotland; USA; India |
英文摘要 | Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental dis-orders such as Fragile X Syndrome (FXS). How developmental changes in neuronal function culminate in network dysfunction that underlies sensory hypersensitivities is unknown. By systematically studying cellular and synaptic properties of layer 4 neurons combined with cellular and network simulations, we explored how the array of phenotypes in Fmr1-knockout (KO) mice produce circuit pathology during development. We show that many of the cellular and synaptic pathologies in Fmr1-KO mice are antagonistic, mitigating circuit dysfunction, and hence may be compensatory to the primary pathology. Overall, the layer 4 network in the Fmr1-KO exhibits significant alterations in spike output in response to thalamocortical input and distorted sensory encoding. This developmental loss of layer 4 sensory encoding precision would contribute to subsequent developmental alterations in layer 4-to-layer 2/3 connectivity and plasticity observed in Fmr1-KO mice, and circuit dysfunction underlying sensory hypersensitivity. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000491858200003 |
WOS关键词 | MENTAL-RETARDATION PROTEIN ; EXCITATORY NEURONAL NETWORK ; SOMATOSENSORY CORTEX ; MESSENGER-RNAS ; DEPENDENT PLASTICITY ; NEOCORTICAL CIRCUIT ; STIMULUS LOCATION ; PYRAMIDAL CELLS ; KNOCKOUT MICE ; KO MICE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203476 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Bristol, Sch Physiol Pharmacol & Neurosci, Bristol, Avon, England; 2.Univ Edinburgh, Ctr Discovery Brain Sci, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland; 3.Univ Edinburgh, Patrick Wild Ctr, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland; 4.NINDS, Dev Synapt Plastic Sect, NIH, Bethesda, MD 20892 USA; 5.Univ Edinburgh, Simons Initiat Developing Brain, Hugh Robson Bldg,George Sq, Edinburgh EH8 9XD, Midlothian, Scotland; 6.NCBS, Ctr Brain Dev & Repair, GKVK Campus, Bangalore 560065, Karnataka, India; 7.Janssen Neurosci, J&J London Innovat Ctr, One Chapel Pl, London W1G 0B, England |
推荐引用方式 GB/T 7714 | Domanski, Aleksander P. F.,Booker, Sam A.,Wyllie, David J. A.,et al. Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Domanski, Aleksander P. F.,Booker, Sam A.,Wyllie, David J. A.,Isaac, John T. R.,&Kind, Peter C..(2019).Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.NATURE COMMUNICATIONS,10. |
MLA | Domanski, Aleksander P. F.,et al."Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex".NATURE COMMUNICATIONS 10(2019). |
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