Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-017-01123-0 |
Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways | |
Mortzfeld, Benedikt M.1,3; Taubenheim, Jan1,4; Klimovich, Alexander, V1; Fraune, Sebastian1,4; Rosenstiel, Philip2; Bosch, Thomas C. G.1 | |
2019-07-22 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA |
英文摘要 | How multicellular organisms assess and control their size is a fundamental question in biology, yet the molecular and genetic mechanisms that control organ or organism size remain largely unsolved. The freshwater polyp Hydra demonstrates a high capacity to adapt its body size to different temperatures. Here we identify the molecular mechanisms controlling this phenotypic plasticity and show that temperature-induced cell number changes are controlled by Wnt- and TGF-beta signaling. Further we show that insulin-like peptide receptor (INSR) and forkhead box protein O (FoxO) are important genetic drivers of size determination controlling the same developmental regulators. Thus, environmental and genetic factors directly affect developmental mechanisms in which cell number is the strongest determinant of body size. These findings identify the basic mechanisms as to how size is regulated on an organismic level and how phenotypic plasticity is integrated into conserved developmental pathways in an evolutionary informative model organism. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000476721900005 |
WOS关键词 | RNA-SEQ READS ; C-ELEGANS ; GROWTH ; MECHANISMS ; EXPRESSION ; ALIGNMENT ; PATTERN ; GENOME ; FOXO ; GENERATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203474 |
专题 | 资源环境科学 |
作者单位 | 1.Christian Albrechts Univ Kiel, Zool Inst, Botan Garten 1-9, D-24118 Kiel, Germany; 2.Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Clin Mol Biol, Rosalind Franklin Str 12, D-24105 Kiel, Germany; 3.Univ Massachusetts, Dept Bioengn, 285 Old Westport Rd, Dartmouth, MA 02747 USA; 4.Heinrich Heine Univ Dusseldorf, Inst Zool & Organism Interact, Univ Str 1, D-40225 Dusseldorf, Germany |
推荐引用方式 GB/T 7714 | Mortzfeld, Benedikt M.,Taubenheim, Jan,Klimovich, Alexander, V,et al. Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Mortzfeld, Benedikt M.,Taubenheim, Jan,Klimovich, Alexander, V,Fraune, Sebastian,Rosenstiel, Philip,&Bosch, Thomas C. G..(2019).Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways.NATURE COMMUNICATIONS,10. |
MLA | Mortzfeld, Benedikt M.,et al."Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论