GSTDTAP  > 资源环境科学
DOI10.1038/s41467-017-01123-0
Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
Mortzfeld, Benedikt M.1,3; Taubenheim, Jan1,4; Klimovich, Alexander, V1; Fraune, Sebastian1,4; Rosenstiel, Philip2; Bosch, Thomas C. G.1
2019-07-22
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2019
卷号10
文章类型Article
语种英语
国家Germany; USA
英文摘要

How multicellular organisms assess and control their size is a fundamental question in biology, yet the molecular and genetic mechanisms that control organ or organism size remain largely unsolved. The freshwater polyp Hydra demonstrates a high capacity to adapt its body size to different temperatures. Here we identify the molecular mechanisms controlling this phenotypic plasticity and show that temperature-induced cell number changes are controlled by Wnt- and TGF-beta signaling. Further we show that insulin-like peptide receptor (INSR) and forkhead box protein O (FoxO) are important genetic drivers of size determination controlling the same developmental regulators. Thus, environmental and genetic factors directly affect developmental mechanisms in which cell number is the strongest determinant of body size. These findings identify the basic mechanisms as to how size is regulated on an organismic level and how phenotypic plasticity is integrated into conserved developmental pathways in an evolutionary informative model organism.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000476721900005
WOS关键词RNA-SEQ READS ; C-ELEGANS ; GROWTH ; MECHANISMS ; EXPRESSION ; ALIGNMENT ; PATTERN ; GENOME ; FOXO ; GENERATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/203474
专题资源环境科学
作者单位1.Christian Albrechts Univ Kiel, Zool Inst, Botan Garten 1-9, D-24118 Kiel, Germany;
2.Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Clin Mol Biol, Rosalind Franklin Str 12, D-24105 Kiel, Germany;
3.Univ Massachusetts, Dept Bioengn, 285 Old Westport Rd, Dartmouth, MA 02747 USA;
4.Heinrich Heine Univ Dusseldorf, Inst Zool & Organism Interact, Univ Str 1, D-40225 Dusseldorf, Germany
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GB/T 7714
Mortzfeld, Benedikt M.,Taubenheim, Jan,Klimovich, Alexander, V,et al. Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways[J]. NATURE COMMUNICATIONS,2019,10.
APA Mortzfeld, Benedikt M.,Taubenheim, Jan,Klimovich, Alexander, V,Fraune, Sebastian,Rosenstiel, Philip,&Bosch, Thomas C. G..(2019).Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways.NATURE COMMUNICATIONS,10.
MLA Mortzfeld, Benedikt M.,et al."Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways".NATURE COMMUNICATIONS 10(2019).
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