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DOI | 10.1038/s41467-017-00966-x |
Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons | |
Chen, Yu-Sheng1; Solel, Ephrath2; Huang, Yi-Fan3; Wang, Chien-Lung3; Tu, Tsung-Han1; Keinan, Ehud2; Chan, Yi-Tsu1 | |
2019-08-01 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Taiwan; Israel |
英文摘要 | Self-assembly of twelve pentatopic tectons, which have complementary edges or can be linked using either digonal or trigonal connectors, represents the optimal synthetic strategy to achieve spherical objects, such as chemical capsids. This process requires conditions that secure uninterrupted equilibria of binding and self-correction en route to the global energy minimum. Here we report the synthesis of a highly soluble, deca-heterosubstituted corannulene that bears five terpyridine ligands. Spontaneous self-assembly of twelve such tectons with 30 cadmium(II) cations produces a giant icosahedral capsid as a thermodynamically stable single product in high yield. Nuclear magnetic resonance (NMR) methods, mass spectrometry analyses, small-angle X-ray scattering, transmission electron microscopy, and atomic force microscopy indicate that this spherical capsid has an external diameter of nearly 6 nm and shell thickness of 1 nm, in agreement with molecular modeling. NMR and liquid chromatography evidences imply that chiral self-sorting complexation generates a racemic mixture of homochiral capsids. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000478013400004 |
WOS关键词 | COMPLEXES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203468 |
专题 | 资源环境科学 |
作者单位 | 1.Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan; 2.Technion Israel Inst Technol, Schulich Fac Chem, IL-32000 Haifa, Israel; 3.Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 30010, Taiwan |
推荐引用方式 GB/T 7714 | Chen, Yu-Sheng,Solel, Ephrath,Huang, Yi-Fan,et al. Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Chen, Yu-Sheng.,Solel, Ephrath.,Huang, Yi-Fan.,Wang, Chien-Lung.,Tu, Tsung-Han.,...&Chan, Yi-Tsu.(2019).Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons.NATURE COMMUNICATIONS,10. |
MLA | Chen, Yu-Sheng,et al."Chemical mimicry of viral capsid self-assembly via corannulene-based pentatopic tectons".NATURE COMMUNICATIONS 10(2019). |
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