Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-017-00256-6 |
Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology | |
Plassais, Jocelyn1; Kim, Jaemin1; Davis, Brian W.1,2; Karyadi, Danielle M.1,3; Hogan, Andrew N.1; Harris, Alex C.1; Decker, Brennan1,4; Parker, Heidi G.1; Ostrander, Elaine A.1 | |
2019-04-02 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and breed-associated behaviors resulting from human selective pressures. To identify the genetic underpinnings of such traits, we analyze 722 canine whole genome sequences (WGS), documenting over 91 million single nucleotide and small indels, creating a large catalog of genomic variation for a companion animal species. We undertake both selective sweep analyses and genome wide association studies (GWAS) inclusive of over 144 modern breeds, 54 wild canids and a hundred village dogs. Our results identify variants of strong impact associated with 16 phenotypes, including body weight variation which, when combined with existing data, explain greater than 90% of body size variation in dogs. We thus demonstrate that GWAS and selection scans performed with WGS are powerful complementary methods for expanding the utility of companion animal systems for the study of mammalian growth and biology. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462985600007 |
WOS关键词 | DOMESTIC DOG ; BODY-MASS ; ASSOCIATION ; EFFICIENT ; MODEL ; SIZE ; ARCHITECTURE ; HISTORY ; TRAITS ; GENES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203411 |
专题 | 资源环境科学 |
作者单位 | 1.NHGRI, Canc Genet & Comparat Genom Branch, NIH, Bethesda, MD 20892 USA; 2.Texas A&M Univ, College Stn, TX 77840 USA; 3.NCI, Lab Genet Susceptibil, NIH, Rockville, MD 20850 USA; 4.Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Plassais, Jocelyn,Kim, Jaemin,Davis, Brian W.,et al. Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Plassais, Jocelyn.,Kim, Jaemin.,Davis, Brian W..,Karyadi, Danielle M..,Hogan, Andrew N..,...&Ostrander, Elaine A..(2019).Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology.NATURE COMMUNICATIONS,10. |
MLA | Plassais, Jocelyn,et al."Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology".NATURE COMMUNICATIONS 10(2019). |
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