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DOI | 10.1038/s41467-017-00347-4 |
Electrical pulse-induced electrochemical biosensor for hepatitis E virus detection | |
Chowdhury, Ankan Dutta1; Takemura, Kenshin2; Li, Tian-Cheng3; Suzuki, Tetsuro4; Park, Enoch Y.1,2 | |
2019-08-19 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | Hepatitis E virus (HEV) is one of the leading causes of acute viral hepatitis worldwide. In this work, a pulse-triggered ultrasensitive electrochemical sensor was fabricated using graphene quantum dots and gold-embedded polyaniline nanowires, prepared via an interfacial polymerization and then self-assembly approach. Introducing an external electrical pulse during the virus accumulation step increases the sensitivity towards HEV due to the expanded surface of the virus particle as well as the antibody-conjugated polyaniline chain length, compared to other conventional electrochemical sensors. The sensor was applied to various HEV genotypes, including G1, G3, G7 and ferret HEV obtained from cell culture supernatant and in a series of fecal specimen samples collected from G7 HEV-infected monkey. The sensitivity is similar to that detected by real-time quantitative reverse transcription-polymerase chain (RT-qPCR). These results suggests that the proposed sensor can pave the way for the development of robust, high-performance sensing methodologies for HEV detection. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000481607000007 |
WOS关键词 | GRAPHENE QUANTUM DOTS ; IN-SITU GROWTH ; IMPEDIMETRIC BIOSENSOR ; SENSITIVE DETECTION ; SELECTIVE DETECTION ; GOLD NANOPARTICLES ; INFLUENZA-VIRUS ; OXIDE ; GLUCOSE ; ASSAY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203408 |
专题 | 资源环境科学 |
作者单位 | 1.Shizuoka Univ, Res Inst Green Sci & Technol, Suruga Ku, 836 Ohya, Shizuoka 4228529, Japan; 2.Shizuoka Univ, Grad Sch Sci & Technol, Dept Biosci, Suruga Ku, 836 Ohya, Shizuoka 4228529, Japan; 3.Natl Inst Infect Dis, Dept Virol 2, 4-7-1 Gakuen, Musashimurayam, Tokyo 2080011, Japan; 4.Hamamatsu Univ Sch Med, Dept Infect Dis, Hamamatsu, Shizuoka 4313125, Japan |
推荐引用方式 GB/T 7714 | Chowdhury, Ankan Dutta,Takemura, Kenshin,Li, Tian-Cheng,et al. Electrical pulse-induced electrochemical biosensor for hepatitis E virus detection[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Chowdhury, Ankan Dutta,Takemura, Kenshin,Li, Tian-Cheng,Suzuki, Tetsuro,&Park, Enoch Y..(2019).Electrical pulse-induced electrochemical biosensor for hepatitis E virus detection.NATURE COMMUNICATIONS,10. |
MLA | Chowdhury, Ankan Dutta,et al."Electrical pulse-induced electrochemical biosensor for hepatitis E virus detection".NATURE COMMUNICATIONS 10(2019). |
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