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DOI | 10.1038/s41467-017-00114-5 |
Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA | |
Cingolani, Gino1,2; McCauley, Michael3,5; Lobley, Anna3; Bryer, Alexander J.4; Wesolowski, Jordan3; Greco, Deanna L.4; Lokareddy, Ravi K.1; Ronzone, Erik3,6; Perilla, Juan R.4; Paumet, Fabienne3 | |
2019-06-21 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Italy |
英文摘要 | Many intracellular bacteria, including Chlamydia, establish a parasitic membrane-bound organelle inside the host cell that is essential for the bacteria's survival. Chlamydia trachomatis forms inclusions that are decorated with poorly characterized membrane proteins known as Incs. The prototypical Inc, called IncA, enhances Chlamydia pathogenicity by promoting the homotypic fusion of inclusions and shares structural and functional similarity to eukaryotic SNAREs. Here, we present the atomic structure of the cytoplasmic domain of IncA, which reveals a non-canonical four-helix bundle. Structure-based mutagenesis, molecular dynamics simulation, and functional cellular assays identify an intramolecular clamp that is essential for IncA-mediated homotypic membrane fusion during infection. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000472480500014 |
WOS关键词 | CLINICAL-MANIFESTATIONS ; MEMBRANE-PROTEINS ; TRACHOMATIS ; PHENIX ; MODEL ; EPIDEMIOLOGY ; CONSERVATION ; VESICLE ; SERVER ; CORE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203391 |
专题 | 资源环境科学 |
作者单位 | 1.Thomas Jefferson Univ, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA; 2.CNR, Inst Biomembranes & Bioenerget, Via Amendola 165-A, I-70126 Bari, Italy; 3.Thomas Jefferson Univ, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA; 4.Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA; 5.Janssen Res & Dev, Spring House, PA 19477 USA; 6.VUE Hlth, Boston, MA 02110 USA |
推荐引用方式 GB/T 7714 | Cingolani, Gino,McCauley, Michael,Lobley, Anna,et al. Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Cingolani, Gino.,McCauley, Michael.,Lobley, Anna.,Bryer, Alexander J..,Wesolowski, Jordan.,...&Paumet, Fabienne.(2019).Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA.NATURE COMMUNICATIONS,10. |
MLA | Cingolani, Gino,et al."Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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