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DOI | 10.1038/s41467-017-00094-6 |
Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy | |
Froeb, Franziska1; Sock, Elisabeth1; Tamm, Ernst. R.2; Saur, Anna-Lena1; Hillgaertner, Simone1; Williams, Trevor J.3,4; Fujii, Toshihiro5; Fukunaga, Rikiro5; Wegner, Michael1 | |
2019-05-29 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA; Japan |
英文摘要 | Schwann cells ensure efficient nerve impulse conduction in the peripheral nervous system. Their development is accompanied by defined chromatin changes, including variant histone deposition and redistribution. To study the importance of variant histones for Schwann cell development, we altered their genomic distribution by conditionally deleting Ep400, the central subunit of the Tip60/Ep400 complex. Ep400 absence causes peripheral neuropathy in mice, characterized by terminal differentiation defects in myelinating and non-myelinating Schwann cells and immune cell activation. Variant histone H2A.Z is differently distributed throughout the genome and remains at promoters of Tfap2a, Pax3 and other transcriptional regulator genes with transient function at earlier developmental stages. Tfap2a deletion in Ep400-deficient Schwann cells causes a partial rescue arguing that continued expression of early regulators mediates the phenotypic defects. Our results show that proper genomic distribution of variant histones is essential for Schwann cell differentiation, and assign importance to Ep400-containing chromatin remodelers in the process. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000469320900003 |
WOS关键词 | CHROMATIN-REMODELING ATPASE ; TRANSCRIPTION FACTOR AP-2 ; HISTONE VARIANT H2A.Z ; MARIE-TOOTH-DISEASE ; GENE ; MYELINATION ; SOX10 ; DIFFERENTIATION ; EXCHANGE ; IDENTIFICATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203366 |
专题 | 资源环境科学 |
作者单位 | 1.Friedrich Alexander Univ Erlangen Nurnberg, Inst Biochem, Emil Fischer Zentrum, Fahrstr 17, D-91054 Erlangen, Germany; 2.Univ Regensburg, Inst Humananat & Embryol, Univ Str 31, D-93053 Regensburg, Germany; 3.UC Denver, Dept Craniofacial Biol, Anschutz Med Campus, 12801 East 17th Ave, Aurora, CO 80045 USA; 4.UC Denver, Dept Cell & Dev Biol, Anschutz Med Campus, 12801 East 17th Ave, Aurora, CO 80045 USA; 5.Osaka Univ Pharmaceut Sci, Dept Biochem, 4-20-1 Nasahara, Takatsuki, Osaka 5691094, Japan |
推荐引用方式 GB/T 7714 | Froeb, Franziska,Sock, Elisabeth,Tamm, Ernst. R.,et al. Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Froeb, Franziska.,Sock, Elisabeth.,Tamm, Ernst. R..,Saur, Anna-Lena.,Hillgaertner, Simone.,...&Wegner, Michael.(2019).Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.NATURE COMMUNICATIONS,10. |
MLA | Froeb, Franziska,et al."Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy".NATURE COMMUNICATIONS 10(2019). |
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