Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms15425 |
The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis | |
Romero-Moreno, Ricardo1,2; Curtis, Kimberly J.1,3; Coughlin, Thomas R.1,3; Miranda-Vergara, Maria Cristina1,2; Dutta, Shourik1,2; Natarajan, Aishwarya1,2; Facchine, Beth A.1,2; Jackson, Kristen M.1,3; Nystrom, Lukas5,6; Li, Jun1,4; Kaliney, William1; Niebur, Glen L.1,3; Littlepage, Laurie E.1,2 | |
2019-09-27 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble factors from conditioned media identifies the chemokine CXCL5 as a candidate to induce metastatic colonization. Additional studies using CXCL5 recombinant protein suggest that CXCL5 is sufficient to promote breast cancer cell proliferation and colonization in bone, while inhibition of its receptor CXCR2 with an antagonist blocks proliferation of metastatic cancer cells. This study suggests that CXCL5 and CXCR2 inhibitors may have efficacy in treating metastatic bone tumors dependent on the CXCL5/CXCR2 axis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000488232600012 |
WOS关键词 | DISSEMINATED TUMOR-CELLS ; ZOLEDRONIC ACID ; CXCL5 ; MARROW ; CXCR2 ; MECHANISMS ; PREVENTION ; CHEMOKINES ; RECEPTORS ; MIGRATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203348 |
专题 | 资源环境科学 |
作者单位 | 1.Harper Canc Res Inst, South Bend, IN 46617 USA; 2.Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA; 3.Univ Notre Dame, Dept Aerosp & Mech Engn, Tissue Mech Lab, Notre Dame, IN 46556 USA; 4.Univ Notre Dame, Dept Appl & Computat Math & Stat, Notre Dame, IN 46556 USA; 5.Loyola Univ, Med Ctr, Stritch Sch Med, Dept Orthopaed Surg & Rehabil, 2160 S 1st Ave, Maywood, IL 60153 USA; 6.Cleveland Clin, Dept Orthopaed Surg, Cleveland, OH 44106 USA |
推荐引用方式 GB/T 7714 | Romero-Moreno, Ricardo,Curtis, Kimberly J.,Coughlin, Thomas R.,et al. The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Romero-Moreno, Ricardo.,Curtis, Kimberly J..,Coughlin, Thomas R..,Miranda-Vergara, Maria Cristina.,Dutta, Shourik.,...&Littlepage, Laurie E..(2019).The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis.NATURE COMMUNICATIONS,10. |
MLA | Romero-Moreno, Ricardo,et al."The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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