Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms15735 |
Atypical functional connectome hierarchy in autism | |
Hong, Seok-Jun1,2; de Wael, Reinder Vos1; Bethlehem, Richard A. I.3; Lariviere, Sara1; Paquola, Casey1; Valk, Sofie L.4,5; Milham, Michael P.2,6; Di Martino, Adriana7; Margulies, Daniel S.8; Smallwood, Jonathan9; Bernhardt, Boris C.1 | |
2019-03-04 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; USA; England; Germany; France |
英文摘要 | One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance-specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000460125400004 |
WOS关键词 | DEFAULT-MODE NETWORK ; SPECTRUM DISORDER ; SYMPTOM SEVERITY ; CONNECTIVITY MRI ; BRAIN ; CHILDREN ; ORGANIZATION ; ACTIVATION ; COGNITION ; REGIONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203332 |
专题 | 资源环境科学 |
作者单位 | 1.McGill Univ, Multimodal Imaging & Connectome Anal Lab, McConnell Brain Imaging Ctr, Montreal Neurol Inst & Hosp, Montreal, PQ H3A 2B4, Canada; 2.Child Mind Inst, Ctr Dev Brain, New York, NY 10022 USA; 3.Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB28AH, England; 4.Heinrich Heine Univ, Inst Syst Neurosci, Fac Med, D-40225 Dusseldorf, Germany; 5.Res Ctr Julich, Inst Neurosci & Med INM 7 Brain & Behav, D-52425 Julich, Germany; 6.Nathan S Kline Inst Psychiat Res, Ctr Biomed Imaging & Neuromodulat, Orangeburg, NY 10962 USA; 7.Child Mind Inst, Autism Ctr, New York, NY 10022 USA; 8.UPMC, Inst Cerveau & Moelle Epiniere, CNRS, UMRS 1127,UMR 7225,Frontlab,Inserm,U1127, F-7225 Paris, France; 9.Univ York, Dept Psychol, Heslington YO10 4PH, England |
推荐引用方式 GB/T 7714 | Hong, Seok-Jun,de Wael, Reinder Vos,Bethlehem, Richard A. I.,et al. Atypical functional connectome hierarchy in autism[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Hong, Seok-Jun.,de Wael, Reinder Vos.,Bethlehem, Richard A. I..,Lariviere, Sara.,Paquola, Casey.,...&Bernhardt, Boris C..(2019).Atypical functional connectome hierarchy in autism.NATURE COMMUNICATIONS,10. |
MLA | Hong, Seok-Jun,et al."Atypical functional connectome hierarchy in autism".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论