Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms15591 |
Mouse models of Loa loa | |
Pionnier, Nicolas P.1; Sjoberg, Hanna1; Chunda, Valerine C.2,3; Fombad, Fanny F.2,3; Chounna, Patrick W.2,3; Njouendou, Abdel J.2,3; Metuge, Haelly M.2,3; Ndzeshang, Bertrand L.2,3; Gandjui, Narcisse, V2,3; Akumtoh, Desmond N.2,3; Tayong, Dizzle B.2,3; Taylor, Mark J.1; Wanji, Samuel2,3; Turner, Joseph D.1 | |
2019-03-29 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Cameroon |
英文摘要 | Elimination of the helminth disease, river blindness, remains challenging due to ivermectin treatment-associated adverse reactions in loiasis co-infected patients. Here, we address a deficit in preclinical research tools for filarial translational research by developing Loa loa mouse infection models. We demonstrate that adult Loa loa worms in subcutaneous tissues, circulating microfilariae (mf) and presence of filarial biomarkers in sera occur following experimental infections of lymphopenic mice deficient in interleukin (IL)-2/7 gamma-chain signaling. A microfilaraemic infection model is also achievable, utilizing immune-competent or -deficient mice infused with purified Loa mf. Ivermectin but not benzimidazole treatments induce rapid decline (>90%) in parasitaemias in microfilaraemic mice. We identify upregulation of inflammatory markers associated with allergic type-2 immune responses and eosinophilia post-ivermectin treatment. Thus, we provide validation of murine research models to identify loiasis biomarkers, to counter-screen candidate river blindness cures and to interrogate the inflammatory etiology of loiasis ivermectin-associated adverse reactions. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462721900028 |
WOS关键词 | ONCHOCERCIASIS ; IVERMECTIN ; INFECTION ; FILARIASIS ; CELLS ; DIETHYLCARBAMAZINE ; MICROFILARIAE ; DISCOVERY ; EXPANSION ; BIOMARKER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203326 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Liverpool Liverpool Sch Trop Med, Ctr Drugs & Diagnost Res, Dept Trop Dis Biol, Pembroke Pl, Liverpool L3 5QA, Merseyside, England; 2.Res Fdn Trop Dis & Environm, POB 474, Buea, Cameroon; 3.Univ Buea, Parasite & Vector Biol Res Unit, Dept Microbiol & Parasitol, Fac Sci, POB 63, Buea, Cameroon |
推荐引用方式 GB/T 7714 | Pionnier, Nicolas P.,Sjoberg, Hanna,Chunda, Valerine C.,et al. Mouse models of Loa loa[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Pionnier, Nicolas P..,Sjoberg, Hanna.,Chunda, Valerine C..,Fombad, Fanny F..,Chounna, Patrick W..,...&Turner, Joseph D..(2019).Mouse models of Loa loa.NATURE COMMUNICATIONS,10. |
MLA | Pionnier, Nicolas P.,et al."Mouse models of Loa loa".NATURE COMMUNICATIONS 10(2019). |
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