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DOI | 10.1038/ncomms15596 |
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria | |
Xing, Meining1; Wei, Yifeng2; Zhou, Yan1; Zhang, Jun1; Lin, Lianyun1; Hu, Yiling1; Hua, Gaoqun1; Urs, Ankanahalli N. Nanjaraj1; Liu, Dazhi1; Wang, Feifei1; Guo, Cuixia1; Tong, Yang1; Li, Mengya1; Liu, Yanhong3; Ang, Ee Lui2; Zhao, Huimin2,4; Yuchi, Zhiguang1; Zhang, Yan1 | |
2019-04-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; Singapore; USA |
英文摘要 | Bacterial degradation of organosulfonates plays an important role in sulfur recycling, and has been extensively studied. However, this process in anaerobic bacteria especially gut bacteria is little known despite of its potential significant impact on human health with the production of toxic H2S. Here, we describe the structural and biochemical characterization of an oxygen-sensitive enzyme that catalyzes the radical-mediated C-S bond cleavage of isethionate to form sulfite and acetaldehyde. We demonstrate its involvement in pathways that enables C2 sulfonates to be used as terminal electron acceptors for anaerobic respiration in sulfate- and sulfite-reducing bacteria. Furthermore, it plays a key role in converting bile salt-derived taurine into H2S in the disease-associated gut bacterium Bilophila wadsworthia. The enzymes and transporters in these anaerobic pathways expand our understanding of microbial sulfur metabolism, and help deciphering the complex web of microbial pathways involved in the transformation of sulfur compounds in the gut. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000463695400024 |
WOS关键词 | SULFATE-REDUCING BACTERIA ; ELECTRON-ACCEPTORS ; GENE CLUSTERS ; TAURINE ; ENZYME ; METABOLISM ; PURIFICATION ; PROTEIN ; DECARBOXYLASE ; DISSIMILATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203321 |
专题 | 资源环境科学 |
作者单位 | 1.Tianjin Univ, Sch Pharmaceut Sci & Technol, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China; 2.ASTAR, Inst Chem & Engn Sci, Metab Engn Res Lab, Singapore 138669, Singapore; 3.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China; 4.Univ Illinois, Dept Chem & Biomol Engn, 600 South Mathews Ave, Urbana, IL 61801 USA |
推荐引用方式 GB/T 7714 | Xing, Meining,Wei, Yifeng,Zhou, Yan,et al. Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Xing, Meining.,Wei, Yifeng.,Zhou, Yan.,Zhang, Jun.,Lin, Lianyun.,...&Zhang, Yan.(2019).Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.NATURE COMMUNICATIONS,10. |
MLA | Xing, Meining,et al."Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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