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DOI | 10.1038/ncomms15597 |
Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor | |
Anderson, Samantha L.1; Boyd, Peter G.1; Gladysiak, Andrzej1; Nguyen, Tu N.1; Palgrave, Robert G.2; Kubicki, Dominik3; Emsley, Lyndon3; Bradshaw, Darren4; Rosseinsky, Matthew J.5; Smit, Berend1; Stylianou, Kyriakos C.1 | |
2019-04-08 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; England |
英文摘要 | Biologically derived metal-organic frameworks (bio-MOFs) are of great importance as they can be used as models for bio-mimicking and in catalysis, allowing us to gain insights into how large biological molecules function. Through rational design, here we report the synthesis of a novel bio-MOF featuring unobstructed Watson-Crick faces of adenine (Ade) pointing towards the MOF cavities. We show, through a combined experimental and computational approach, that thymine (Thy) molecules diffuse through the pores of the MOF and become base-paired with Ade. The Ade-Thy pair binding at 40-45% loading reveals that Thy molecules are packed within the channels in a way that fulfill both the Woodward-Hoffmann and Schmidt rules, and upon UV irradiation, Thy molecules dimerize into Thy<>Thy. This study highlights the utility of accessible functional groups within the pores of MOFs, and their ability to 'lock' molecules in specific positions that can be subsequently dimerized upon light irradiation, extending the use of MOFs as nanoreactors for the synthesis of molecules that are otherwise challenging to isolate. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000463695400027 |
WOS关键词 | THYMINE DIMERIZATION ; POROUS MATERIALS ; CRYSTAL ; DNA ; SELECTIVITY ; CAPTURE ; SYSTEMS ; LIGHT ; MOFS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203313 |
专题 | 资源环境科学 |
作者单位 | 1.Ecole Polytech Fed Lausanne EPFL Valais Wallis, ISIC, Lab Mol Simulat LSMO, Rue Ind 17, CH-1951 Sion, Switzerland; 2.UCL, Dept Chem, 20 Gordon St, London WC1H 0AJ, England; 3.Ecole Polytech Fed Lausanne, ISIC, Lab Magnet Resonance LRM, CH-1015 Lausanne, Switzerland; 4.Univ Southampton, Sch Chem, Highfield Campus, Southampton SO17 1BJ, Hants, England; 5.Univ Liverpool, Dept Chem, Crown St, Liverpool L69 7ZD, Merseyside, England |
推荐引用方式 GB/T 7714 | Anderson, Samantha L.,Boyd, Peter G.,Gladysiak, Andrzej,et al. Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Anderson, Samantha L..,Boyd, Peter G..,Gladysiak, Andrzej.,Nguyen, Tu N..,Palgrave, Robert G..,...&Stylianou, Kyriakos C..(2019).Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor.NATURE COMMUNICATIONS,10. |
MLA | Anderson, Samantha L.,et al."Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor".NATURE COMMUNICATIONS 10(2019). |
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