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DOI | 10.1038/ncomms15548 |
Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling | |
Hamnett, Ryan1,2; Crosby, Priya1; Chesham, Johanna E.1; Hastings, Michael H.1 | |
2019-02-01 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; USA |
英文摘要 | The suprachiasmatic nucleus (SCN) co-ordinates circadian behaviour and physiology in mammals. Its cell-autonomous circadian oscillations pivot around a well characterised transcriptional/translational feedback loop (TTFL), whilst the SCN circuit as a whole is synchronised to solar time by its retinorecipient cells that express and release vasoactive intestinal peptide (VIP). The cell-autonomous and circuit-level mechanisms whereby VIP synchronises the SCN are poorly understood. We show that SCN slices in organotypic culture demonstrate rapid and sustained circuit-level circadian responses to VIP that are mediated at a cell-autonomous level. This is accompanied by changes across a broad transcriptional network and by significant VIP-directed plasticity in the internal phasing of the cell-autonomous TTFL. Signalling via ERK1/2 and tuning by its negative regulator DUSP4 are critical elements of the VIP-directed circadian re-programming. In summary, we provide detailed mechanistic insight into VIP signal transduction in the SCN at the level of genes, cells and neural circuit. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000457440700007 |
WOS关键词 | FUNCTIONAL-ANALYSIS ; VPAC(2) RECEPTOR ; CELLULAR CLOCKS ; GENE-EXPRESSION ; PHOTIC INPUT ; PHASE-SHIFTS ; IN-VITRO ; NUCLEUS ; LIGHT ; ENTRAINMENT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203311 |
专题 | 资源环境科学 |
作者单位 | 1.MRC Lab Mol Biol, Francis Crick Ave, Cambridge CB2 0QH, England; 2.Stanford Univ, Dept Neurosurg, 318 Campus Dr, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Hamnett, Ryan,Crosby, Priya,Chesham, Johanna E.,et al. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Hamnett, Ryan,Crosby, Priya,Chesham, Johanna E.,&Hastings, Michael H..(2019).Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.NATURE COMMUNICATIONS,10. |
MLA | Hamnett, Ryan,et al."Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling".NATURE COMMUNICATIONS 10(2019). |
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