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DOI | 10.1038/ncomms15101 |
Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer | |
Merino, D.1,2,3,4; Weber, T. S.2,5; Serrano, A.1,2,3; Vaillant, F.1,2; Liu, K.1,2; Pal, B.1,2; Di Stefano, L.6; Schreuder, J.2,5,7; Lin, D.2,5,7; Chen, Y.2,6; Asselin-Labat, M. L.1,2; Schumacher, T. N.8; Cameron, D.6; Smyth, G. K.6,9; Papenfuss, A. T.2,6,9,10,11; Lindeman, G. J.1,12,13,14,15; Visvader, J. E.1,2; Naik, S. H.2,5,7 | |
2019-02-15 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Australia; Netherlands |
英文摘要 | Primary triple negative breast cancers (TNBC) are prone to dissemination but sub-clonal relationships between tumors and resulting metastases are poorly understood. Here we use cellular barcoding of two treatment-naive TNBC patient-derived xenografts (PDXs) to track the spatio-temporal fate of thousands of barcoded clones in primary tumors, and their metastases. Tumor resection had a major impact on reducing clonal diversity in secondary sites, indicating that most disseminated tumor cells lacked the capacity to 'seed', hence originated from 'shedders', that did not persist. The few clones that continued to grow after resection i.e. 'seeders', did not correlate in frequency with their parental clones in primary tumors. Cisplatin treatment of one BRCA1-mutated PDX model to non-palpable levels had a surprisingly minor impact on clonal diversity in the relapsed tumor yet purged 50% of distal clones. Therefore, clonal features of shedding, seeding and drug resistance are important factors to consider for the design of therapeutic strategies. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000458754700009 |
WOS关键词 | INTRA-TUMOR HETEROGENEITY ; MUTATIONAL EVOLUTION ; DYNAMICS ; KINETICS ; DIVERSE ; MODELS ; CELLS ; LUNG |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203260 |
专题 | 资源环境科学 |
作者单位 | 1.Walter & Eliza Hall Inst Med Res, ACRF Stem Cells & Canc Div, Parkville, Vic 3052, Australia; 2.Univ Melbourne, Dept Med Biol, Melbourne, Vic 3010, Australia; 3.Olivia Newton John Canc Res Inst, Heidelberg, Vic 3084, Australia; 4.La Trobe Univ, Sch Canc Med, Bundoora, Vic 3086, Australia; 5.Walter & Eliza Hall Inst Med Res, Mol Med Div, Parkville, Vic 3052, Australia; 6.Walter & Eliza Hall Inst Med Res, Bioinformat Div, Parkville, Vic 3052, Australia; 7.Walter & Eliza Hall Inst Med Res, Immunol Div, Parkville, Vic 3052, Australia; 8.Netherlands Canc Inst, Div Mol Oncol & Immunol, NL-1066 CX Amsterdam, Netherlands; 9.Univ Melbourne, Sch Math & Stat, Melbourne, Vic 3010, Australia; 10.Peter MacCallum Canc Ctr, Melbourne, Vic 3000, Australia; 11.Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia; 12.Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic 3000, Australia; 13.Univ Melbourne, Dept Med, Melbourne, Vic 3010, Australia; 14.Royal Melbourne Hosp, Parkville Familial Canc Ctr, Parkville, Vic 3050, Australia; 15.Peter MacCallum Canc Ctr, Parkville, Vic 3050, Australia |
推荐引用方式 GB/T 7714 | Merino, D.,Weber, T. S.,Serrano, A.,et al. Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Merino, D..,Weber, T. S..,Serrano, A..,Vaillant, F..,Liu, K..,...&Naik, S. H..(2019).Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer.NATURE COMMUNICATIONS,10. |
MLA | Merino, D.,et al."Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer".NATURE COMMUNICATIONS 10(2019). |
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