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DOI | 10.1038/ncomms14730 |
Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait | |
van den Berg, Niels1,2,3; Rodriguez-Girondo, Mar4; van Dijk, Ingrid K.3; Mourits, Rick J.3; Mandemakers, Kees5; Janssens, Angelique A. P. O.3; Beekman, Marian1; Smith, Ken R.2; Slagboom, P. Eline1,6 | |
2019-01-07 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Netherlands; USA; Germany |
英文摘要 | Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is challenging. There is debate concerning the survival percentile that best isolates the genetic component in longevity. Here, we use three-generational mortality data from two large datasets, UPDB (US) and LINKS (Netherlands). We study 20,360 unselected families containing index persons, their parents, siblings, spouses, and children, comprising 314,819 individuals. Our analyses provide strong evidence that longevity is transmitted as a quantitative genetic trait among survivors up to the top 10% of their birth cohort. We subsequently show a survival advantage, mounting to 31%, for individuals with top 10% surviving first and second-degree relatives in both data-bases and across generations, even in the presence of non-longevous parents. To guide future genetic studies, we suggest to base case selection on top 10% survivors of their birth cohort with equally long-lived family members. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000455042100001 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; LONG-LIVED FAMILIES ; LIFE-SPAN ; EXCEPTIONAL LONGEVITY ; HISTORICAL DEMOGRAPHY ; MORTALITY ; CENTENARIANS ; POPULATION ; SIBLINGS ; HERITABILITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203257 |
专题 | 资源环境科学 |
作者单位 | 1.Leiden Univ, Med Ctr, Sect Mol Epidemiol, Dept Biomed Data Sci, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands; 2.Univ Utah, Dept Family & Consumer Studies, Huntsman Canc Inst, Populat Sci, 225 S 1400 E Rm 228, Salt Lake City, UT 84112 USA; 3.Radboud Univ Nijmegen, Radboud Grp Hist Demog & Family Hist, Erasmuspl 1, NL-6525 HT Nijmegen, Netherlands; 4.Leiden Univ, Med Ctr, Sect Med Stat, Dept Biomed Data Sci, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands; 5.Int Inst Social Hist, Cruquiusweg 31, NL-1019 AT Amsterdam, Netherlands; 6.Max Planck Inst Biol Ageing, Joseph Stelzmann Str 9b, D-50931 Cologne, Germany |
推荐引用方式 GB/T 7714 | van den Berg, Niels,Rodriguez-Girondo, Mar,van Dijk, Ingrid K.,et al. Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait[J]. NATURE COMMUNICATIONS,2019,10. |
APA | van den Berg, Niels.,Rodriguez-Girondo, Mar.,van Dijk, Ingrid K..,Mourits, Rick J..,Mandemakers, Kees.,...&Slagboom, P. Eline.(2019).Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait.NATURE COMMUNICATIONS,10. |
MLA | van den Berg, Niels,et al."Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait".NATURE COMMUNICATIONS 10(2019). |
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