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DOI | 10.1038/ncomms14868 |
The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis | |
Capalbo, Luisa1; 39;Avino, Pier Paolo2 | |
2019-10-04 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Italy; Switzerland |
英文摘要 | The midbody is an organelle assembled at the intercellular bridge between the two daughter cells at the end of mitosis. It controls the final separation of the daughter cells and has been involved in cell fate, polarity, tissue organization, and cilium and lumen formation. Here, we report the characterization of the intricate midbody protein-protein interaction network (interactome), which identifies many previously unknown interactions and provides an extremely valuable resource for dissecting the multiple roles of the midbody. Initial analysis of this interactome revealed that PP1 beta-MYPT1 phosphatase regulates microtubule dynamics in late cytokinesis and de-phosphorylates the kinesin component MKLP1/KIF23 of the centralspindlin complex. This de-phosphorylation antagonizes Aurora B kinase to modify the functions and interactions of centralspindlin in late cytokinesis. Our findings expand the repertoire of PP1 functions during mitosis and indicate that spatiotemporal changes in the distribution of kinases and counteracting phosphatases finely tune the activity of cytokinesis proteins. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000489013700006 |
WOS关键词 | CITRON KINASE CONTROLS ; AURORA B ; ABSCISSION ; PLATFORM ; KINESIN ; MITOSIS ; RHOA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203256 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Cambridge, Dept Pathol, Tennis Court Rd, Cambridge CB2 1QP, England; 2.Univ Cambridge, Dept Genet, Downing St, Cambridge CB2 3EH, England; 3.Univ Siena, Dept Med Biotechnol, Via A Moro 4, I-53100 Siena, Italy; 4.Univ Siena, Dept Life Sci, Via A Moro 4, I-53100 Siena, Italy; 5.Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England; 6.Univ Cambridge, Cambridge Syst Biol Ctr, Tennis Court Rd, Cambridge CB2 1QR, England; 7.Univ Nottingham, Sch Life Sci, Nottingham NG7 2UH, England; 8.Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England; 9.Univ Warwick, Warwick Med Sch, Ctr Mechanochem Cell Biol, Coventry CV4 7AL, W Midlands, England; 10.Univ Warwick, Warwick Med Sch, Div Biomed Sci, Coventry CV4 7AL, W Midlands, England; 11.Univ Cambridge, Dept Biochem, Cambridge, England; 12.Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England; 13.Novartis Inst BioMed Res, Autoimmun Transplantat & Inflammat Bioninfomat, CH-4056 Basel, Switzerland; 14.Francis Crick Inst, Chromosome Replicat Lab, 1 Midland Rd, London NW1 1AT, England |
推荐引用方式 GB/T 7714 | Capalbo, Luisa,39;Avino, Pier Paolo. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Capalbo, Luisa,&39;Avino, Pier Paolo.(2019).The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis.NATURE COMMUNICATIONS,10. |
MLA | Capalbo, Luisa,et al."The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis".NATURE COMMUNICATIONS 10(2019). |
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