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DOI | 10.1038/ncomms14894 |
Time-dependent assessment of stimulus-evoked regional dopamine release | |
Lippert, Rachel N.1; Cremer, Anna Lena1; Thanarajah, Sharmili Edwin1,2; Korn, Clio3,4; Jahans-Price, Thomas4; Burgeno, Lauren M.4; Tittgemeyer, Marc1,5,6; Bruening, Jens C.1,5,7; Walton, Mark E.4,8; Backes, Heiko1 | |
2019-01-18 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; England; USA |
英文摘要 | To date, the spatiotemporal release of specific neurotransmitters at physiological levels in the human brain cannot be detected. Here, we present a method that relates minute-by-minute fluctuations of the positron emission tomography (PET) radioligand [11C]raclopride directly to subsecond dopamine release events. We show theoretically that synaptic dopamine release induces low frequency temporal variations of extrasynaptic extracellular dopamine levels, at time scales of one minute, that can evoke detectable temporal variations in the [11C] raclopride signal. Hence, dopaminergic activity can be monitored via temporal fluctuations in the [11C] raclopride PET signal. We validate this theory using fast-scan cyclic voltammetry and [11C] raclopride PET in mice during chemogenetic activation of dopaminergic neurons. We then apply the method to data from human subjects given a palatable milkshake and discover immediate and-for the first time-delayed food-induced dopamine release. This method enables time-dependent regional monitoring of stimulus-evoked dopamine release at physiological levels. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000456012000008 |
WOS关键词 | IN-VIVO ; KINETIC DIVERSITY ; RECEPTOR-BINDING ; C-11 RACLOPRIDE ; HUMAN-BRAIN ; PET ; LIGAND ; NEUROTRANSMISSION ; TRANSMISSION ; AFFINITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203245 |
专题 | 资源环境科学 |
作者单位 | 1.Max Planck Inst Metab Res, Gleueler Str 50, D-50931 Cologne, Germany; 2.Univ Hosp Cologne, Dept Neurol, Kerpener Str 62, D-50937 Cologne, Germany; 3.Univ Oxford, Dept Psychiat, Warneford Hosp, Oxford OX3 7JX, England; 4.Univ Oxford, Dept Expt Psychol, Tinsley Bldg,Mansfield Rd, Oxford OX1 3SR, England; 5.Cologne Cluster Excellence Cellular Stress & Agin, Joseph Stelzmann Str 26, D-50931 Cologne, Germany; 6.Modern Diet & Physiol Res Ctr, 290 Congress Ave, New Haven, CT 06519 USA; 7.Univ Hosp Cologne, Ctr Endocrinol Diabet & Prevent Med CEPD, Kerpener Str 62, D-50937 Cologne, Germany; 8.Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Dept Expt Psychol, Tinsley Bldg,Mansfield Rd, Oxford OX1 3SR, England |
推荐引用方式 GB/T 7714 | Lippert, Rachel N.,Cremer, Anna Lena,Thanarajah, Sharmili Edwin,et al. Time-dependent assessment of stimulus-evoked regional dopamine release[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Lippert, Rachel N..,Cremer, Anna Lena.,Thanarajah, Sharmili Edwin.,Korn, Clio.,Jahans-Price, Thomas.,...&Backes, Heiko.(2019).Time-dependent assessment of stimulus-evoked regional dopamine release.NATURE COMMUNICATIONS,10. |
MLA | Lippert, Rachel N.,et al."Time-dependent assessment of stimulus-evoked regional dopamine release".NATURE COMMUNICATIONS 10(2019). |
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