Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms14067 |
The transferability of lipid loci across African, Asian and European cohorts | |
Kuchenbaecker, Karoline1,2,3; Telkar, Nikita4; Reiker, Theresa3,5,6,7; Walters, Robin G.8,9,10; Lin, Kuang9,10; Eriksson, Anders11; Gurdasani, Deepti3; Gilly, Arthur3,12; Southam, Lorraine3,12,13; Tsafantakis, Emmanouil14; Karaleftheri, Maria15; Seeley, Janet16,17,18,19,20; Kamali, Anatoli18,19,20; Asiki, Gershim18,19,20,21,22; Millwood, Iona Y.8,9,10; Holmes, Michael8,9,10; Du, Huaidong8,9,10; Guo, Yu23; Kumari, Meena24; Dedoussis, George25; Li, Liming26; Chen, Zhengming9,10; Sandhu, Manjinder S.27; Zeggini, Eleftheria3,12; Benzeval, Michaela24; Burton, Jonathan24; Buck, Nicholas24; Jackle, Annette24; Laurie, Heather24; Lynn, Peter24; Pudney, Stephen24; Rabe, Birgitta24; Wolke, Dieter28 | |
2019-09-24 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Switzerland; Germany; Greece; Uganda; Kenya; Sweden; Peoples R China |
英文摘要 | Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r= 0.23-0.28, p < 1.9 x 10(-14)). Overall, there is evidence of reproducibility for -75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan samples (10% of loci). Individual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000487357600003 |
WOS关键词 | GENETIC ASSOCIATIONS ; WIDE ASSOCIATION ; BLOOD-LIPIDS ; MIXED-MODEL ; VARIANTS ; GENOMICS ; BIOBANK ; DISEASE ; TRAITS ; HEALTH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203216 |
专题 | 资源环境科学 |
作者单位 | 1.UCL, Div Psychiat, London W1T 7NF, England; 2.UCL, Genet Inst, London WC1E 6BT, England; 3.Wellcome Sanger Inst, Dept Human Genet, Hinxton CB10 1SA, England; 4.UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England; 5.Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England; 6.Swiss Trop & Publ Hlth Inst, Basel, Switzerland; 7.Univ Basel, Basel, Switzerland; 8.Univ Oxford, MRC PHRU, Nuffield Dept Populat Hlth, Oxford, England; 9.Univ Oxford, Nuffield Dept Populat Hlth, CTSU, Oxford, England; 10.Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England; 11.Kings Coll London, Dept Med & Mol Genet, London SE1 9RT, England; 12.German Res Ctr Environm Hlth, Inst Translat Genom, Helmholtz Zentrum Munchen, Neuherberg, Germany; 13.Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England; 14.Anogia Med Ctr, Anogia 74051, Greece; 15.Echinos Med Ctr, Xanthi 67300, Greece; 16.London Sch Hyg & Trop Med, Dept Global Hlth & Dev, London WC1E 7HT, England; 17.London Sch Hyg & Trop Med, Fac Publ Hlth & Policy, London WC1E 7HT, England; 18.Uganda Virus Res Inst, MRC, Entebbe, Uganda; 19.London Sch Hyg MRC UVRI, Entebbe, Uganda; 20.LSHTM, Uganda Res Unit, Entebbe, Uganda; 21.African Populat & Hlth Res Ctr, Nairobi, Kenya; 22.Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden; 23.Chinese Acad Med Sci, Beijing 100730, Peoples R China; 24.Univ Essex, Inst Social & Econ Res, Wivenhoe Pk, Colchester CO4 35Q, Essex, England; 25.Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece; 26.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China; 27.Univ Cambridge, Dept Med, Cambridge CB2 0QQ, England; 28.Univ Warwick, Dept Psychol, Coventry CV4 7AL, W Midlands, England |
推荐引用方式 GB/T 7714 | Kuchenbaecker, Karoline,Telkar, Nikita,Reiker, Theresa,et al. The transferability of lipid loci across African, Asian and European cohorts[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Kuchenbaecker, Karoline.,Telkar, Nikita.,Reiker, Theresa.,Walters, Robin G..,Lin, Kuang.,...&Wolke, Dieter.(2019).The transferability of lipid loci across African, Asian and European cohorts.NATURE COMMUNICATIONS,10. |
MLA | Kuchenbaecker, Karoline,et al."The transferability of lipid loci across African, Asian and European cohorts".NATURE COMMUNICATIONS 10(2019). |
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