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| DOI | 10.1038/ncomms14194 |
| The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression | |
| Lazareth, Helene1,2,3,4; Henique, Carole1,2,5; Lenoir, Olivia1,2; Puelles, Victor G.6,7,8,9; Flamant, Martin; Bollee, Guillaume1,2; Fligny, Cecile1,2; Camus, Marine1,2; Guyonnet, Lea10; Millien, Corinne1,2; Gaillard, Francois1,2; Chipont, Anna1,2; Robin, Blaise1,2; Fabrega, Sylvie11; Dhaun, Neeraj12; Camerer, Eric1,2; Kretz, Oliver7,13; Grahammer, Florian7,13; Braun, Fabian7,13; Huber, Tobias B.7,13; Nochy, Dominique14; Mandet, Chantal14; Bruneval, Patrick14; Mesnard, Laurent15; Thervet, Eric2,3; Karras, Alexandre2,3; Le Naour, Francois16; Rubinstein, Eric1,17; Boucheix, Claude1,17; Alexandrou, Antigoni4; Moeller, Marcus J.; Bouzigues, Cedric4; Tharaux, Pierre-Louis1,2,3 | |
| 2019-07-24 | |
| 发表期刊 | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| 出版年 | 2019 |
| 卷号 | 10 |
| 文章类型 | Article |
| 语种 | 英语 |
| 国家 | France; Germany; Australia; Luxembourg; Scotland |
| 英文摘要 | The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show that expression of the tetraspanin CD9 increases markedly in PECs in mouse models of CGN and FSGS, and in kidneys from individuals diagnosed with these diseases. Cd9 gene targeting in PECs prevents glomerular damage in CGN and FSGS mouse models. Mechanistically, CD9 deficiency prevents the oriented migration of PECs into the glomerular tuft and their acquisition of CD44 and beta 1 integrin expression. These findings highlight a critical role for de novo expression of CD9 as a common pathogenic switch driving the PEC phenotype in CGN and FSGS, while offering a potential therapeutic avenue to treat these conditions. |
| 领域 | 资源环境 |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000476877400002 |
| WOS关键词 | FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; DIPHTHERIA-TOXIN RECEPTOR ; GROWTH-FACTOR ; INTEGRIN ALPHA-3-BETA-1 ; EXPRESSION ; MEMBRANE ; ACTIVATION ; PODOCYTES ; BETA(1) ; COMPLEX |
| WOS类目 | Multidisciplinary Sciences |
| WOS研究方向 | Science & Technology - Other Topics |
| URL | 查看原文 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203201 |
| 专题 | 资源环境科学 |
| 作者单位 | 1.Inserm, Unit 970, Paris Cardiovasc Ctr PARCC, 56 Rue Leblanc, F-75015 Paris, France; 2.Univ Paris, UMR S970, 56 Rue Leblanc, F-75015 Paris, France; 3.Univ Paris, AP HP, Georges Pompidou European Hosp, Renal Div, F-75015 Paris, France; 4.Univ Paris Saclay, INSERM U1182, CNRS UMR7645, Lab Opt & Biosci,Ecole Polytech, F-91128 Palaiseau, France; 5.Univ Paris Est Creteil, Equipe 21, Inserm U955, Inst Mondor Rech Biomed, F-94010 Creteil, France; 6.Univ Hosp RWTH Aachen, Dept Nephrol & Clin Immunol, Pauwelsstr 30, D-52074 Aachen, Germany; 7.Univ Med Ctr Hamburg Eppendorf, Fac Med, Dept Med 3, D-20246 Hamburg, Germany; 8.Monash Univ, Dept Nephrol, Melbourne, Vic 3168, Australia; 9.Monash Univ, Ctr Inflammatory Dis, Melbourne, Vic 3168, Australia; 10.Univ Paris, Xavier Bichat Univ Hosp, F-75018 Paris, France; 11.Luxembourg Inst Hlth, Dept Infect & Immun, Natl Cytometry Platform, L-4354 Luxembourg, Luxembourg; 12.Univ Paris, Hop Necker Enfants Malades, IFR94, Inst Imagine Plateforme Vecteurs Viraux & Transfe, F-75015 Paris, France; 13.Royal Infirm Edinburgh NHS Trust, Dept Renal Med, Edinburgh EH16 4SA, Midlothian, Scotland; 14.Univ Freiburg, Fac Med, Med Ctr, Renal Div, D-79106 Freiburg, Germany; 15.Georges Pompidou European Hosp, AP HP, Dept Pathol, F-75015 Paris, France; 16.Pierre & Marie Curie Univ, Hop Tenon, AP HP, Crit Care Nephrol & Kidney Transplantat,Unite Mi, F-75020 Paris, France; 17.Univ Paris Sud, Inserm U1193, F-94800 Villejuif, France; 18.Univ Paris Sud, Inserm U935, F-94800 Villejuif, France |
| 推荐引用方式 GB/T 7714 | Lazareth, Helene,Henique, Carole,Lenoir, Olivia,et al. The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression[J]. NATURE COMMUNICATIONS,2019,10. |
| APA | Lazareth, Helene.,Henique, Carole.,Lenoir, Olivia.,Puelles, Victor G..,Flamant, Martin.,...&Tharaux, Pierre-Louis.(2019).The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression.NATURE COMMUNICATIONS,10. |
| MLA | Lazareth, Helene,et al."The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression".NATURE COMMUNICATIONS 10(2019). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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