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DOI | 10.1038/ncomms14434 |
Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis | |
Barger, Sarah R.1; Reilly, Nicholas S.2; Shutova, Maria S.3; Li, Qingsen4; Maiuri, Paolo4; Heddleston, John M.5; Mooseker, Mark S.6; Flavell, Richard A.7,8; Svitkina, Tatyana3; Oakes, Patrick W.2,9; Krendel, Mira1; Gauthier, Nils C.4 | |
2019-03-19 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Italy |
英文摘要 | Phagocytosis of invading pathogens or cellular debris requires a dramatic change in cell shape driven by actin polymerization. For antibody-covered targets, phagocytosis is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface, leading to the extension and closure of the phagocytic cup around the target. We find that two actin-dependent molecular motors, class 1 myosins myosin le and myosin if, are specifically localized to Fc-receptor adhesions and required for efficient phagocytosis of antibody-opsonized targets. Using primary macrophages lacking both myosin le and myosin if, we find that without the actin-membrane linkage mediated by these myosins, the organization of individual adhesions is compromised, leading to excessive actin polymerization, slower adhesion turnover, and deficient phagocytic internalization. This work identifies a role for class 1 myosins in coordinated adhesion turnover during phagocytosis and supports a mechanism involving membrane-cytoskeletal crosstalk for phagocytic cup closure. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000461557200001 |
WOS关键词 | FC-GAMMA-R ; PHOSPHATIDYLINOSITOL 3-KINASE ; MECHANICAL-PROPERTIES ; PLASMA-MEMBRANE ; LEADING-EDGE ; ACTIN WAVES ; MACROPHAGES ; TENSION ; EXOCYTOSIS ; MICROSCOPY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203200 |
专题 | 资源环境科学 |
作者单位 | 1.SUNY Upstate Med Univ, Cell & Dev Biol Dept, Syracuse, NY 13210 USA; 2.Univ Rochester, Dept Phys, Rochester, NY 14627 USA; 3.Univ Penn, Dept Biol, Philadelphia, PA 19104 USA; 4.IFOM, FIRC Inst Mol Oncol, I-20139 Milan, Italy; 5.Howard Hughes Med Inst, Adv Imaging Ctr, Janelia Res Campus, Ashburn, VA 20147 USA; 6.Yale Univ, Mol Cellular & Dev Biol, New Haven, CT 06520 USA; 7.Yale Univ, Dept Immunobiol, Sch Med, New Haven, CT 06519 USA; 8.Yale Univ, Howard Hughes Med Inst, New Haven, CT 06519 USA; 9.Univ Rochester, Dept Biol, Rochester, NY 14627 USA |
推荐引用方式 GB/T 7714 | Barger, Sarah R.,Reilly, Nicholas S.,Shutova, Maria S.,et al. Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Barger, Sarah R..,Reilly, Nicholas S..,Shutova, Maria S..,Li, Qingsen.,Maiuri, Paolo.,...&Gauthier, Nils C..(2019).Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis.NATURE COMMUNICATIONS,10. |
MLA | Barger, Sarah R.,et al."Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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