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DOI | 10.1038/ncomms14322 |
Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch | |
Tao, Hirotaka1; Zhu, Min1,2,3; Lau, Kimberly1; Whitley, Owen K. W.1; Samani, Mohammad1; Xiao, Xiao1; Chen, Xiao Xiao1,4; Hahn, Noah A.1,4; Liu, Weifan1,4; Valencia, Megan4; Wu, Min4; Wang, Xian2,3; Fenelon, Kelli D.1,4; Pasiliao, Clarissa C.1,4; Hu, Di1; Wu, Jinchun1; Spring, Shoshana5; Ferguson, James6; Karuna, Edith P.7; Henkelman, R. Mark5; Dunn, Alexander8; Huang, Huaxiong9; Ho, Hsin-Yi Henry7; Atit, Radhika6; Goyal, Sidhartha10; Sun, Yu2,3; Hopyan, Sevan1,4,11,12 | |
2019-04-12 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; USA |
英文摘要 | Multiple vertebrate embryonic structures such as organ primordia are composed of confluent cells. Although mechanisms that shape tissue sheets are increasingly understood, those which shape a volume of cells remain obscure. Here we show that 3D mesenchymal cell intercalations are essential to shape the mandibular arch of the mouse embryo. Using a genetically encoded vinculin tension sensor that we knock-in to the mouse genome, we show that cortical force oscillations promote these intercalations. Genetic loss-and gain-offunction approaches show that Wnt5a functions as a spatial cue to coordinate cell polarity and cytoskeletal oscillation. These processes diminish tissue rigidity and help cells to overcome the energy barrier to intercalation. YAP/TAZ and PIEZO1 serve as downstream effectors of Wnt5a-mediated actomyosin polarity and cytosolic calcium transients that orient and drive mesenchymal cell intercalations. These findings advance our understanding of how developmental pathways regulate biophysical properties and forces to shape a solid organ primordium. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464338100014 |
WOS关键词 | NEMATOSTELLA-VECTENSIS OCCURS ; CONVERGENT EXTENSION ; CRANIOFACIAL DEVELOPMENT ; MOUSE ; GASTRULATION ; MORPHOGENESIS ; MUTATIONS ; POLARITY ; MODEL ; MICE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203197 |
专题 | 资源环境科学 |
作者单位 | 1.Hosp Sick Children, Res Inst, Program Dev & Stem Cell Biol, Toronto, ON M5G 0A4, Canada; 2.Univ Toronto, Dept Mech & Ind Engn, Toronto, ON M5S 3G8, Canada; 3.Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G8, Canada; 4.Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada; 5.Univ Toronto, Hosp Sick Children, Dept Med Biophys, Mouse Imaging Ctr, Toronto, ON M5T 3H7, Canada; 6.Case Western Reserve Univ, Dept Biol, Cleveland, OH 44106 USA; 7.Univ Calif Davis, Dept Cell Biol & Human Anat, Sch Med, Davis, CA 95616 USA; 8.Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA; 9.York Univ, Dept Math & Stat, Toronto, ON M3P 1P3, Canada; 10.Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada; 11.Hosp Sick Children, Div Orthopaed Surg, Toronto, ON M5G 1X8, Canada; 12.Univ Toronto, Toronto, ON M5G 1X8, Canada |
推荐引用方式 GB/T 7714 | Tao, Hirotaka,Zhu, Min,Lau, Kimberly,et al. Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Tao, Hirotaka.,Zhu, Min.,Lau, Kimberly.,Whitley, Owen K. W..,Samani, Mohammad.,...&Hopyan, Sevan.(2019).Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.NATURE COMMUNICATIONS,10. |
MLA | Tao, Hirotaka,et al."Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch".NATURE COMMUNICATIONS 10(2019). |
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