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DOI | 10.1038/ncomms14302 |
Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes | |
van der Poel, Marlijn1; Ulas, Thomas2; Mizee, Mark R.1; Hsiao, Cheng-Chih3; Miedema, Suzanne S. M.1; Adelia4; Schuurman, Karianne G.1; Helder, Boy3,5; Tas, Sander W.3,5; Schultze, Joachim L.2,6; Hamann, Jorg1,3; Huitinga, Inge1 | |
2019-03-13 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Netherlands; Germany |
英文摘要 | Here we report the transcriptional profile of human microglia, isolated from normal-appearing grey matter (GM) and white matter (WM) of multiple sclerosis (MS) and non-neurological control donors, to find possible early changes related to MS pathology. Microglia show a clear region-specific profile, indicated by higher expression of type-I interferon genes in GM and higher expression of NF-KB pathway genes in WM. Transcriptional changes in MS microglia also differ between GM and WM. MS WM microglia show increased lipid metabolism gene expression, which relates to MS pathology since active MS lesion-derived microglial nuclei show similar altered gene expression. Microglia from MS GM show increased expression of genes associated with glycolysis and iron homeostasis, possibly reflecting microglia reacting to iron depositions. Except for ADGRG1/GPR56, expression of homeostatic genes, such as P2RY12 and TMEM119, is unaltered in normal-appearing MS tissue, demonstrating overall preservation of microglia homeostatic functions in the initiation phase of MS. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000461021900001 |
WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; GENE ; INFLAMMATION ; EXPRESSION ; PACKAGE ; IRON ; DEGENERATION ; PIOGLITAZONE ; PHYSIOLOGY ; PATHOLOGY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203193 |
专题 | 资源环境科学 |
作者单位 | 1.Netherlands Inst Neurosci, Neuroimmunol Res Grp, Meibergdreef 47, NL-1105 BA Amsterdam, Netherlands; 2.Univ Bonn, LIMES Inst, Genom & Immunoregulat, Carl Troll Str 31, D-53115 Bonn, Germany; 3.Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Expt Immunol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands; 4.Netherlands Inst Neurosci, Netherlands Brain Bank, Meibergdreef 47, NL-1105 BA Amsterdam, Netherlands; 5.Univ Amsterdam, Dept Clin Immunol & Rheumatol, Amsterdam Rheumatol & Immunol Ctr, Amsterdam Univ Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands; 6.Univ Bonn, PRECISE Platform Single Cell Genom & Epigen, German Ctr Neurodegenerat Dis, Sigmund Freud St 27, D-53127 Bonn, Germany |
推荐引用方式 GB/T 7714 | van der Poel, Marlijn,Ulas, Thomas,Mizee, Mark R.,et al. Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes[J]. NATURE COMMUNICATIONS,2019,10. |
APA | van der Poel, Marlijn.,Ulas, Thomas.,Mizee, Mark R..,Hsiao, Cheng-Chih.,Miedema, Suzanne S. M..,...&Huitinga, Inge.(2019).Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes.NATURE COMMUNICATIONS,10. |
MLA | van der Poel, Marlijn,et al."Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes".NATURE COMMUNICATIONS 10(2019). |
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