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DOI | 10.1038/ncomms14220 |
A null model of the mouse whole-neocortex micro-connectome | |
Reimann, Michael W.; Geyaert, Michael; Shi, Ying; Lu, Huanxiang; Markram, Henry; Muller, Eilif | |
2019-08-29 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale connectomics, studying connectivity between individual neurons. We combine these two complementary views of connectomics to build a first draft statistical model of the micro-connectome of a whole mouse neocortex based on available data on region-to-region connectivity and individual whole-brain axon reconstructions. This process reveals a targeting principle that allows us to predict the innervation logic of individual axons from meso-scale data. The resulting connectome recreates biological trends of targeting on all scales and predicts that an established principle of scale invariant topological organization of connectivity can be extended down to the level of individual neurons. It can serve as a powerful null model and as a substrate for whole-brain simulations. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483017900013 |
WOS关键词 | ELECTRON-MICROSCOPY ; RECONSTRUCTION ; CONNECTIVITY ; TRACTOGRAPHY ; VOLUME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203189 |
专题 | 资源环境科学 |
作者单位 | Ecole Polytech Fed Lausanne, Blue Brain Project, CH-1015 Lausanne, Switzerland |
推荐引用方式 GB/T 7714 | Reimann, Michael W.,Geyaert, Michael,Shi, Ying,et al. A null model of the mouse whole-neocortex micro-connectome[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Reimann, Michael W.,Geyaert, Michael,Shi, Ying,Lu, Huanxiang,Markram, Henry,&Muller, Eilif.(2019).A null model of the mouse whole-neocortex micro-connectome.NATURE COMMUNICATIONS,10. |
MLA | Reimann, Michael W.,et al."A null model of the mouse whole-neocortex micro-connectome".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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