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DOI | 10.1038/ncomms14160 |
Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung | |
Lee, Yu-Cheng1; Kurtova, Antonina, V1,2; Xiao, Jing1; Nikolos, Fotis1; Hayashi, Kazukuni1,2; Tramel, Zoe1; Jain, Antrix3; Chen, Fengju4; Chokshi, Mithil5; Lee, Ciaran5; Bao, Gang5; Zhang, Xiang1; Shen, Jianjun6; Mo, Qianxing7; Jung, Sung Yun3; Rowley, David1; Chan, Keith Syson1,4 | |
2019-05-13 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Metastases account for the majority of cancer deaths. While certain steps of the metastatic cascade are well characterized, identification of targets to block this process remains a challenge. Host factors determining metastatic colonization to secondary organs are particularly important for exploration, as those might be shared among different cancer types. Here, we showed that bladder tumor cells expressing the collagen receptor, CD167a, responded to collagen I stimulation at the primary tumor to promote local invasion and utilized the same receptor to preferentially colonize at airway smooth muscle cells (ASMCs)-a rich source of collagen III in lung. Morphologically, COL3-CD167a-driven metastatic foci are uniquely distinct from typical lung alveolar metastatic lesions and exhibited activation of the CD167a-HSP90-Stat3 axis. Importantly, metastatic lung colonization could be abrogated using an investigational drug that attenuates Stat3 activity, implicating this seed-and-soil interaction as a therapeutic target for eliminating lung metastasis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000467702800004 |
WOS关键词 | BLADDER-CANCER METASTASIS ; EXTRACELLULAR-MATRIX ; STEM-CELLS ; STAT3 ; HEAT-SHOCK-PROTEIN-90 ; CHEMOTHERAPY ; NAPABUCASIN ; PROGRESSION ; REGULATORS ; PATHWAY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203176 |
专题 | 资源环境科学 |
作者单位 | 1.Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA; 2.Baylor Coll Med, Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA; 3.Baylor Coll Med, Dept Biochem & Mol Biol, Mass Spectrometry Prote Core, Houston, TX 77030 USA; 4.Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA; 5.Rice Univ, Dept Bioengn, Houston, TX 77030 USA; 6.Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA; 7.H Lee Moffitt Canc Ctr & Res Inst, Dept Biostat & Bioinformat, Tampa, FL 33612 USA |
推荐引用方式 GB/T 7714 | Lee, Yu-Cheng,Kurtova, Antonina, V,Xiao, Jing,et al. Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Lee, Yu-Cheng.,Kurtova, Antonina, V.,Xiao, Jing.,Nikolos, Fotis.,Hayashi, Kazukuni.,...&Chan, Keith Syson.(2019).Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung.NATURE COMMUNICATIONS,10. |
MLA | Lee, Yu-Cheng,et al."Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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