Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/nature25139 |
Locally renewing resident synovial macrophages provide a protective barrier for the joint | |
Culemann, Stephan1,2,3; Grueneboom, Anika1,2,3; Angel Nicolas-Avila, Jose4; Weidner, Daniela1,2,3; Laemmle, Katrin Franziska1,2,3; Rothe, Tobias1,2,3; Quintana, Juan A.4; Kirchner, Philipp2,5; Krljanac, Branislav6; Eberhardt, Martin2,7; Ferrazzi, Fulvia2,5; Kretzschmar, Elke8; Schicht, Martin8; Fischer, Kim1,2; Gelse, Kolja9; Faas, Maria1,2,3; Pfeifle, Rene1,2,3; Ackermann, Jochen A.1,2,3; Pachowsky, Milena9; Renner, Nina9; Simon, David1,2; Haseloff, Reiner F.10; Ekici, Arif B.2,5; Baeuerle, Tobias2,11; Blasig, Ingolf E.10; Vera, Julio2,7; Voehringer, David6; Kleyer, Arnd1,2; Paulsen, Friedrich8; Schett, Georg1,2; Hidalgo, Andres4; Kroenke, Gerhard1,2,3 | |
2019-08-29 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2019 |
卷号 | 572期号:7771页码:670-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Spain |
英文摘要 | Macrophages are considered to contribute to chronic inflammatory diseases such as rheumatoid arthritis(1). However, both the exact origin and the role of macrophages in inflammatory joint disease remain unclear. Here we use fate-mapping approaches in conjunction with three-dimensional light-sheet fluorescence microscopy and single-cell RNA sequencing to perform a comprehensive spatiotemporal analysis of the composition, origin and differentiation of subsets of macrophages within healthy and inflamed joints, and study the roles of these macrophages during arthritis. We find that dynamic membranelike structures, consisting of a distinct population of CX(3)CR1(+) tissue-resident macrophages, form an internal immunological barrier at the synovial lining and physically seclude the joint. These barrier-forming macrophages display features that are otherwise typical of epithelial cells, and maintain their numbers through a pool of locally proliferating CX(3)CR1(-) mononuclear cells that are embedded into the synovial tissue. Unlike recruited monocyte-derived macrophages, which actively contribute to joint inflammation, these epithelial-like CX(3)CR1(+) lining macrophages restrict the inflammatory reaction by providing a tight-junctionmediated shield for intra-articular structures. Our data reveal an unexpected functional diversification among synovial macrophages and have important implications for the general role of macrophages in health and disease. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483405500057 |
WOS关键词 | TISSUE MACROPHAGES ; DEFICIENCY ; PHENOTYPE ; MONOCYTES ; DYNAMICS ; REVEALS ; PROGRAM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202832 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Klinikum Erlangen, Dept Internal Med Rheumatol & Immunol 3, Erlangen, Germany; 2.Friedrich Alexander Univ Erlangen Nurnberg FAU, Erlangen, Germany; 3.Univ Klinikum Erlangen, Nikolaus Fiebiger Ctr Mol Med, Erlangen, Germany; 4.Ctr Nacl Invest Cardiovasc Carlos III, Area Cell & Dev Biol, Madrid, Spain; 5.Univ Klinikum Erlangen, Inst Human Genet, Erlangen, Germany; 6.Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Dept Infect Biol, Erlangen, Germany; 7.Univ Klinikum Erlangen, Dept Dermatol, Lab Syst Tumor Immunol, Erlangen, Germany; 8.Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Funct & Clin Anat, Erlangen, Germany; 9.Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Dept Trauma Surg, Erlangen, Germany; 10.Leibniz Res Inst Mol Pharmacol, Berlin, Germany; 11.Univ Klinikum Erlangen, PIPE, Inst Radiol, Erlangen, Germany |
推荐引用方式 GB/T 7714 | Culemann, Stephan,Grueneboom, Anika,Angel Nicolas-Avila, Jose,et al. Locally renewing resident synovial macrophages provide a protective barrier for the joint[J]. NATURE,2019,572(7771):670-+. |
APA | Culemann, Stephan.,Grueneboom, Anika.,Angel Nicolas-Avila, Jose.,Weidner, Daniela.,Laemmle, Katrin Franziska.,...&Kroenke, Gerhard.(2019).Locally renewing resident synovial macrophages provide a protective barrier for the joint.NATURE,572(7771),670-+. |
MLA | Culemann, Stephan,et al."Locally renewing resident synovial macrophages provide a protective barrier for the joint".NATURE 572.7771(2019):670-+. |
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