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DOI | 10.1038/nature24656 |
Identifying the pathways required for coping behaviours associated with sustained pain | |
Huang, Tianwen1,2; Lin, Shing-Hong1,2; Malewicz, Nathalie M.3; Zhang, Yan1,4,5,6; Zhang, Ying1,7,8; Goulding, Martyn; LaMotte, Robert H.3,9; Ma, Qiufu1,2 | |
2019-01-03 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2019 |
卷号 | 565期号:7737页码:86-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Animals and humans display two types of response to noxious stimuli. The first includes reflexive defensive responses that prevent or limit injury; a well-known example of these responses is the quick withdrawal of one's hand upon touching a hot object. When the first-line response fails to prevent tissue damage (for example, a finger is burnt), the resulting pain invokes a second-line coping response-such as licking the injured area to soothe suffering. However, the underlying neural circuits that drive these two strings of behaviour remain poorly understood. Here we show in mice that spinal neurons marked by coexpression of TACl(Cre) and LBX1(Flpo) drive coping responses associated with pain. Ablation of these spinal neurons led to the loss of both persistent licking and conditioned aversion evoked by stimuli (including skin pinching and burn injury) that-in humans-produce sustained pain, without affecting any of the reflexive defensive reactions that we tested. This selective indifference to sustained pain resembles the phenotype seen in humans with lesions of medial thalamic nuclei(1-3). Consistently, spinal TAC1-lineage neurons are connected to medial thalamic nuclei by direct projections and via indirect routes through the superior lateral parabrachial nuclei. Furthermore, the anatomical and functional segregation observed at the spinal level also applies to primary sensory neurons. For example, in response to noxious mechanical stimuli, MRGPRD- and TRPV1-positive nociceptors are required to elicit reflexive and coping responses, respectively. Our study therefore reveals a fundamental subdivision within the cutaneous somatosensory system, and challenges the validity of using reflexive defensive responses to measure sustained pain. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000454708600032 |
WOS关键词 | NOCICEPTIVE SENSATIONS ; IDENTIFICATION ; NEURONS ; TRPA1 ; CIRCUIT ; ITCH ; THALAMOTOMY ; POPULATION ; ACTIVATION ; MECHANISM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202829 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Dana Farber Canc Inst, Boston, MA USA; 2.Harvard Med Sch, Dept Neurobiol, Boston, MA USA; 3.Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06510 USA; 4.Fudan Univ, Fudan Inst Integrat Med, Inst Acupuncture & Moxibust, Shanghai, Peoples R China; 5.Fudan Univ, Dept Integrat Med & Neurobiol, Sch Basic Med Sci, Shanghai, Peoples R China; 6.Wannan Med Coll, Cell Electrophysiol Lab, Wuhu, Peoples R China; 7.Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Neurosci Res Inst, Beijing, Peoples R China; 8.Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Dept Neurobiol,Sch Basic Med Sci,Key Lab Neurosci, Beijing, Peoples R China; 9.Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA |
推荐引用方式 GB/T 7714 | Huang, Tianwen,Lin, Shing-Hong,Malewicz, Nathalie M.,et al. Identifying the pathways required for coping behaviours associated with sustained pain[J]. NATURE,2019,565(7737):86-+. |
APA | Huang, Tianwen.,Lin, Shing-Hong.,Malewicz, Nathalie M..,Zhang, Yan.,Zhang, Ying.,...&Ma, Qiufu.(2019).Identifying the pathways required for coping behaviours associated with sustained pain.NATURE,565(7737),86-+. |
MLA | Huang, Tianwen,et al."Identifying the pathways required for coping behaviours associated with sustained pain".NATURE 565.7737(2019):86-+. |
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