Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/nature23457 |
FTSJ3 is an RNA 2 '-O-methyltransferase recruited by HIV to avoid innate immune sensing | |
Ringeard, Mathieu1; Marchand, Virginie2; Decroly, Etienne3; Motorin, Yuri4; Bennasser, Yamina1 | |
2019-01-24 | |
发表期刊 | NATURE
![]() |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2019 |
卷号 | 565期号:7740页码:500-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | In mammals, 2'-O-methylation of RNA is a molecular signature by which the cellular innate immune system distinguishes endogenous from exogenous messenger RNA1-3. However, the molecular functions of RNA 2'-O-methylation are not well understood. Here we have purified TAR RNA-binding protein (TRBP) and its interacting partners and identified a DICER-independent TRBP complex containing FTSJ3, a putative 2'-O-methyltransferase (2' O-MTase). In vitro and ex vivo experiments show that FTSJ3 is a 2' O-MTase that is recruited to HIV RNA through TRBP. Using RiboMethSeq analysis4, we identified predominantly FTSJ3-dependent 2'-O-methylations at specific residues on the viral genome. HIV-1 viruses produced in FTSJ3 knockdown cells show reduced 2'-O-methylation and trigger expression of type 1 interferons (IFNs) in human dendritic cells through the RNA sensor MDA5. This induction of IFN-a and IFN-beta leads to a reduction in HIV expression. We have identified an unexpected mechanism used by HIV-1 to evade innate immune recognition: the recruitment of the TRBP-FTSJ3 complex to viral RNA and its 2'-O-methylation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000456653500042 |
WOS关键词 | MESSENGER-RNA ; BINDING PROTEIN ; RESTRICTION ; METHYLATION ; SAMHD1 ; SELF ; TRBP |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202778 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Montpellier, CNRS, IGH, Montpellier, France; 2.Univ Lorraine, INSERM, CNRS, Next Generat Sequencing Core Facil,IBSLor,UMS2008, Vandoeuvre Les Nancy, France; 3.Aix Marseille Univ, AFMB, CNRS, Marseille, France; 4.Univ Lorraine, IMoPA, UMR7365, CNRS, Vandoeuvre Les Nancy, France |
推荐引用方式 GB/T 7714 | Ringeard, Mathieu,Marchand, Virginie,Decroly, Etienne,et al. FTSJ3 is an RNA 2 '-O-methyltransferase recruited by HIV to avoid innate immune sensing[J]. NATURE,2019,565(7740):500-+. |
APA | Ringeard, Mathieu,Marchand, Virginie,Decroly, Etienne,Motorin, Yuri,&Bennasser, Yamina.(2019).FTSJ3 is an RNA 2 '-O-methyltransferase recruited by HIV to avoid innate immune sensing.NATURE,565(7740),500-+. |
MLA | Ringeard, Mathieu,et al."FTSJ3 is an RNA 2 '-O-methyltransferase recruited by HIV to avoid innate immune sensing".NATURE 565.7740(2019):500-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论