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DOI | 10.1038/nature22086 |
Identity and dynamics of mammary stem cells during branching morphogenesis | |
Scheele, Colinda L. G. J.1,2; Hannezo, Edouard3,4,5; Muraro, Mauro J.1,2; Zomer, Anoek1,2; Langedijk, Nathalia S. M.1,2; van Oudenaarden, Alexander1,2; Simons, Benjamin D.3,4,5; van Rheenen, Jacco1,2 | |
2017-02-16 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 542期号:7641页码:313-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Netherlands; England |
英文摘要 | During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown. Here we show that morphogenesis is driven by proliferative terminal end buds that terminate or bifurcate with near equal probability, in a stochastic and time-invariant manner, leading to a heterogeneous epithelial network. We show that the majority of terminal end bud cells function as highly proliferative, lineage-committed MaSCs that are heterogeneous in their expression profile and short-term contribution to ductal extension. Yet, through cell rearrangements during terminal end bud bifurcation, each MaSC is able to contribute actively to long-term growth. Our study shows that the behaviour of MaSCs is not directly linked to a single expression profile. Instead, morphogenesis relies upon lineage-restricted heterogeneous MaSC populations that function as single equipotent pools in the long term. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000394451600029 |
WOS关键词 | GLAND DEVELOPMENT ; BASAL LAMINA ; DIFFERENTIATION ; ORGANOGENESIS ; HOMEOSTASIS ; HIERARCHY ; TISSUE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202739 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Hubrecht Inst KNAW, Canc Genom Netherlands, Utrecht, Netherlands; 2.Univ Med Ctr Utrecht, Utrecht, Netherlands; 3.Univ Cambridge, Dept Phys, Cavendish Lab, Cambridge, England; 4.Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge, England; 5.Univ Cambridge, Wellcome Trust Med Res Council Stem Cell Inst, Cambridge CB2 1TN, England |
推荐引用方式 GB/T 7714 | Scheele, Colinda L. G. J.,Hannezo, Edouard,Muraro, Mauro J.,et al. Identity and dynamics of mammary stem cells during branching morphogenesis[J]. NATURE,2017,542(7641):313-+. |
APA | Scheele, Colinda L. G. J..,Hannezo, Edouard.,Muraro, Mauro J..,Zomer, Anoek.,Langedijk, Nathalia S. M..,...&van Rheenen, Jacco.(2017).Identity and dynamics of mammary stem cells during branching morphogenesis.NATURE,542(7641),313-+. |
MLA | Scheele, Colinda L. G. J.,et al."Identity and dynamics of mammary stem cells during branching morphogenesis".NATURE 542.7641(2017):313-+. |
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