Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/nature21058 |
Locomotor speed control circuits in the caudal brainstem | |
Capelli, Paolo1,2; Pivetta, Chiara1,2; Esposito, Maria Soledad1,2; Arber, Silvia1,2 | |
2017-11-16 | |
发表期刊 | NATURE
![]() |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 551期号:7680页码:373-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | Locomotion is a universal behaviour that provides animals with the ability to move between places. Classical experiments have used electrical microstimulation to identify brain regions that promote locomotion1-5, but the identity of neurons that act as key intermediaries between higher motor planning centres and executive circuits in the spinal cord has remained controversial6-14. Here we show that the mouse caudal brainstem encompasses functionally heterogeneous neuronal subpopulations that have differential effects on locomotion. These subpopulations are distinguishable by location, neurotransmitter identity and connectivity. Notably, glutamatergic neurons within the lateral paragigantocellular nucleus (LPGi), a small subregion in the caudal brainstem, are essential to support high-speed locomotion, and can positively tune locomotor speed through inputs from glutamatergic neurons of the upstream midbrain locomotor region. By contrast, glycinergic inhibitory neurons can induce different forms of behavioural arrest mapping onto distinct caudal brainstem regions. Anatomically, descending pathways of glutamatergic and glycinergic LPGi subpopulations communicate with distinct effector circuits in the spinal cord. Our results reveal that behaviourally opposing locomotor functions in the caudal brainstem were historically masked by the unexposed diversity of intermingled neuronal subpopulations. We demonstrate how specific brainstem neuron populations represent essential substrates to implement key parameters in the execution of motor programs. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000415365500041 |
WOS关键词 | MEDULLARY RETICULAR-FORMATION ; INTACT UNANESTHETIZED CAT ; SPINAL-CORD ; FUNCTIONAL-ORGANIZATION ; GABAERGIC NEURONS ; ACTIVATION ; STIMULATION ; GENERATION ; FORELIMB ; VARIANT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202710 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Basel, Biozentrum, Dept Cell Biol, CH-4056 Basel, Switzerland; 2.Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland |
推荐引用方式 GB/T 7714 | Capelli, Paolo,Pivetta, Chiara,Esposito, Maria Soledad,et al. Locomotor speed control circuits in the caudal brainstem[J]. NATURE,2017,551(7680):373-+. |
APA | Capelli, Paolo,Pivetta, Chiara,Esposito, Maria Soledad,&Arber, Silvia.(2017).Locomotor speed control circuits in the caudal brainstem.NATURE,551(7680),373-+. |
MLA | Capelli, Paolo,et al."Locomotor speed control circuits in the caudal brainstem".NATURE 551.7680(2017):373-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论