Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/nature21359 |
Environment dominates over host genetics in shaping human gut microbiota | |
Rothschild, Daphna1,2; Weissbrod, Omer1,2; Barkan, Elad1,2; Kurilshikov, Alexander3; Korem, Tal1,2; Zeevi, David1,2; Costea, Paul I.1,2; Godneva, Anastasia1,2; Kalka, Iris N.1,2; Bar, Noam1,2; Shilo, Smadar1,2; Lador, Dar1,2; Vila, Arnau Vich3,4; Zmora, Niv5,6,7; Pevsner-Fischer, Meirav5; Israeli, David8,9; Kosower, Noa1,2; Malka, Gal1,2; Wolf, Bat Chen1,2; Avnit-Sagi, Tali1,2; Lotan-Pompan, Maya1,2; Weinberger, Adina1,2; Halpern, Zamir7,10; Carmi, Shai11; Fu, Jingyuan3,12; Wijmenga, Cisca3,13; Zhernakova, Alexandra3; Elinav, Eran1,5; Segal, Eran1,2 | |
2018-03-08 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2018 |
卷号 | 555期号:7695页码:210-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Israel; Netherlands; Norway |
英文摘要 | Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426763400043 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; LINEAR MIXED MODELS ; HERITABILITY ; DIVERSITY ; METAGENOMICS ; RELATEDNESS ; PROPORTION ; PREDICTION ; FRAMEWORK ; INFERENCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202704 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Weizmann Inst Sci, Dept Comp Sci & Appl Math, IL-7610001 Rehovot, Israel; 2.Weizmann Inst Sci, Dept Mol Cell Biol, IL-7610001 Rehovot, Israel; 3.Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9713 GZ Groningen, Netherlands; 4.Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, NL-9713 GZ Groningen, Netherlands; 5.Weizmann Inst Sci, Immunol Dept, IL-7610001 Rehovot, Israel; 6.Tel Aviv Sourasky Med Ctr, Internal Med Dept, IL-6423906 Tel Aviv, Israel; 7.Tel Aviv Univ, Res Ctr Digest Tract & Liver Dis, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, IL-6423906 Tel Aviv, Israel; 8.Kfar Shaul Hosp, Jerusalem Ctr Mental Hlth, Day Care Unit, IL-9106000 Jerusalem, Israel; 9.Kfar Shaul Hosp, Jerusalem Ctr Mental Hlth, Lab Imaging & Brain Stimulat, IL-9106000 Jerusalem, Israel; 10.Tel Aviv Sourasky Med Ctr, Digest Ctr, IL-6423906 Tel Aviv, Israel; 11.Hebrew Univ Jerusalem, Braun Sch Publ Hlth & Community Med, IL-9112001 Jerusalem, Israel; 12.Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, NL-9713 GZ Groningen, Netherlands; 13.Univ Oslo, KG Jebsen Coeliac Dis Res Ctr, Dept Immunol, N-0424 Oslo, Norway |
推荐引用方式 GB/T 7714 | Rothschild, Daphna,Weissbrod, Omer,Barkan, Elad,et al. Environment dominates over host genetics in shaping human gut microbiota[J]. NATURE,2018,555(7695):210-+. |
APA | Rothschild, Daphna.,Weissbrod, Omer.,Barkan, Elad.,Kurilshikov, Alexander.,Korem, Tal.,...&Segal, Eran.(2018).Environment dominates over host genetics in shaping human gut microbiota.NATURE,555(7695),210-+. |
MLA | Rothschild, Daphna,et al."Environment dominates over host genetics in shaping human gut microbiota".NATURE 555.7695(2018):210-+. |
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