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DOI | 10.1038/nature21068 |
Structures of the calcium-activated, non-selective cation channel TRPM4 | |
Guo, Jiangtao1,2; She, Ji1,2; Zeng, Weizhong1,2,3; Chen, Qingfeng1,2,3; Bai, Xiao-chen2,4; Jiang, Youxing1,2,3 | |
2017-12-14 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 552期号:7684页码:205-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P-2)-modulated, non-selective cation channel that belongs to the family of melastatin-related transient receptor potential (TRPM) channels. Here we present the electron cryo-microscopy structures of the mouse TRPM4 channel with and without ATP. TRPM4 consists of multiple transmembrane and cytosolic domains, which assemble into a three-tiered architecture. The N-terminal nucleotide-binding domain and the C-terminal coiled-coil participate in the tetrameric assembly of the channel; ATP binds at the nucleotide-binding domain and inhibits channel activity. TRPM4 has an exceptionally wide filter but is only permeable to monovalent cations; filter residue Gln973 is essential in defining monovalent selectivity. The S1-S4 domain and the post-S6 TRP domain form the central gating apparatus that probably houses the Ca2+- and PtdIns(4,5)P-2-binding sites. These structures provide an essential starting point for elucidating the complex gating mechanisms of TRPM4 and reveal the molecular architecture of the TRPM family. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000418029500037 |
WOS关键词 | KINASE ; NUCLEOTIDES ; SENSITIVITY ; VALIDATION ; NANODISCS ; PROTEIN ; SODIUM ; SYSTEM ; DOMAIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202685 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Texas Southwestern Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA; 2.Univ Texas Southwestern Med Ctr Dallas, Dept Biophys, Dallas, TX 75390 USA; 3.Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA; 4.Univ Texas Southwestern Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA |
推荐引用方式 GB/T 7714 | Guo, Jiangtao,She, Ji,Zeng, Weizhong,et al. Structures of the calcium-activated, non-selective cation channel TRPM4[J]. NATURE,2017,552(7684):205-+. |
APA | Guo, Jiangtao,She, Ji,Zeng, Weizhong,Chen, Qingfeng,Bai, Xiao-chen,&Jiang, Youxing.(2017).Structures of the calcium-activated, non-selective cation channel TRPM4.NATURE,552(7684),205-+. |
MLA | Guo, Jiangtao,et al."Structures of the calcium-activated, non-selective cation channel TRPM4".NATURE 552.7684(2017):205-+. |
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