Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw2719 |
Microbial metabolites control the thymic development of mucosal-associated invariant T cells | |
Legoux, Francois1; Bellet, Deborah2; Daviaud, Celine1,3; El Morr, Yara1; Darbois, Aurelie1; Niort, Kristina4; Procopio, Emanuele1; Salou, Marion1; Gilet, Jules1; Ryffel, Bernhard5; Balvay, Aurelie2; Foussier, Anne2; Sarkis, Manal1,6; El Marjou, Ahmed4; Schmidt, Frederic6; Rabot, Sylvie2; Lantz, Olivier1,7,8 | |
2019-10-25 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6464页码:494-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | How the microbiota modulate immune functions remains poorly understood. Mucosal-associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in germ-free mice. Here, we show that commensal bacteria govern murine MAIT intrathymic development, as MAIT cells did not recirculate to the thymus. MAIT development required RibD expression in bacteria, indicating that production of the MAIT antigen 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU) was necessary. 5-OP-RU rapidly traveled from mucosal surfaces to the thymus, where it was captured by the major histocompatibility complex class Ib molecule MR1. This led to increased numbers of the earliest MAIT precursors and the expansion of more mature receptor-related, orphan receptor gamma t-positive MAIT cells. Thus, a microbiota-derived metabolite controls the development of mucosally targeted T cells in a process blurring the distinction between exogenous antigens and self-antigens. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000493177900048 |
WOS关键词 | MOUSE ; MAIT ; RIBOFLAVIN ; SELECTION ; MR1 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202644 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.PSL Univ, Inst Curie, INSERM, U932, F-75005 Paris, France; 2.Univ Paris Saclay, AgroParisTech, INRA, Micalis Inst, F-78350 Jouy En Josas, France; 3.Inst Curie, Anim Facil, F-75005 Paris, France; 4.Inst Curie, Recombinant Prot Facil, F-75005 Paris, France; 5.Univ Orleans, CNRS, UMR7355, F-45060 Orleans, France; 6.PSL Univ, Inst Curie, INSERM, U1143,CNRS,UMR3666, F-75005 Paris, France; 7.Inst Curie, Lab Immunol Clin, F-75005 Paris, France; 8.Inst Curie, Ctr Invest Clin Biotherapie, Gustave Roussy Inst Curie CIC BT1428, F-75005 Paris, France |
推荐引用方式 GB/T 7714 | Legoux, Francois,Bellet, Deborah,Daviaud, Celine,et al. Microbial metabolites control the thymic development of mucosal-associated invariant T cells[J]. SCIENCE,2019,366(6464):494-+. |
APA | Legoux, Francois.,Bellet, Deborah.,Daviaud, Celine.,El Morr, Yara.,Darbois, Aurelie.,...&Lantz, Olivier.(2019).Microbial metabolites control the thymic development of mucosal-associated invariant T cells.SCIENCE,366(6464),494-+. |
MLA | Legoux, Francois,et al."Microbial metabolites control the thymic development of mucosal-associated invariant T cells".SCIENCE 366.6464(2019):494-+. |
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