Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aax6624 |
MAIT cells are imprinted by the microbiota in early life and promote tissue repair | |
Constantinides, Michael G.1; Link, Verena M.1; Tamoutounour, Samira1,10; Wong, Andrea C.2; Perez-Chaparro, P. Juliana3; Han, Seong-Ji1; Chen, Y. Erin4; Li, Kelin5; Farhat, Sepideh6; Weckel, Antonin6; Krishnamurthy, Siddharth R.1; Vujkovic-Cvijin, Ivan1; Linehan, Jonathan L.1,11; Bouladoux, Nicolas1,3; Merrill, E. Dean1; Roy, Sobhan7; Cua, Daniel J.8,12; Adams, Erin J.7; Bhandoola, Avinash9; Scharschmidt, Tiffany C.6; Aube, Jeffrey6; Fischbach, Michael A.4; Belkaid, Yasmine1,3 | |
2019-10-25 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6464页码:445-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; France |
英文摘要 | How early-life colonization and subsequent exposure to the microbiota affect long-term tissue immunity remains poorly understood. Here, we show that the development of mucosal-associated invariant T (MAIT) cells relies on a specific temporal window, after which MAIT cell development is permanently impaired. This imprinting depends on early-life exposure to defined microbes that synthesize riboflavin-derived antigens. In adults, cutaneous MAIT cells are a dominant population of interleukin-17A (IL-17A)-producing lymphocytes, which display a distinct transcriptional signature and can subsequently respond to skin commensals in an IL-1-, IL-18-, and antigen-dependent manner. Consequently, local activation of cutaneous MAIT cells promotes wound healing. Together, our work uncovers a privileged interaction between defined members of the microbiota and MAIT cells, which sequentially controls both tissue-imprinting and subsequent responses to injury. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000493177900038 |
WOS关键词 | INVARIANT T-CELLS ; SKIN IMMUNITY ; GUT MICROBIOTA ; INNATE ; MOUSE ; LYMPHOCYTES ; HOMEOSTASIS ; METABOLITES ; MATURATION ; TOLERANCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202638 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA; 2.Univ Penn, Immunol Grad Grp, Philadelphia, PA 19104 USA; 3.NIAID, NIAID Microbiome Program, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA; 4.Stanford Univ, Dept Bioengn & ChEM H, Stanford, CA 94305 USA; 5.Univ N Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Chapel Hill, NC 27599 USA; 6.Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA; 7.Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA; 8.Merck & Co Inc, Merck Res Labs, Palo Alto, CA 94304 USA; 9.NCI, Lab Genome Integr, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 10.LOreal Res & Innovat, F-93600 Aulnay Sous Bois, France; 11.Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA; 12.Janssen Res & Dev, Spring House, PA 19477 USA |
推荐引用方式 GB/T 7714 | Constantinides, Michael G.,Link, Verena M.,Tamoutounour, Samira,et al. MAIT cells are imprinted by the microbiota in early life and promote tissue repair[J]. SCIENCE,2019,366(6464):445-+. |
APA | Constantinides, Michael G..,Link, Verena M..,Tamoutounour, Samira.,Wong, Andrea C..,Perez-Chaparro, P. Juliana.,...&Belkaid, Yasmine.(2019).MAIT cells are imprinted by the microbiota in early life and promote tissue repair.SCIENCE,366(6464),445-+. |
MLA | Constantinides, Michael G.,et al."MAIT cells are imprinted by the microbiota in early life and promote tissue repair".SCIENCE 366.6464(2019):445-+. |
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