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DOI | 10.1126/science.aay0616 |
Isolated cortical computations during delta waves support memory consolidation | |
Todorova, Ralitsa; Zugaro, Michael | |
2019-10-18 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6463页码:377-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Delta waves have been described as periods of generalized silence across the cortex, and their alternation with periods of endogenous activity results in the slow oscillation of slow-wave sleep. Despite evidence that delta waves are instrumental for memory consolidation, their specific role in reshaping cortical functional circuits remains puzzling. In a rat model, we found that delta waves are not periods of complete silence and that the residual activity is not mere neuronal noise. Instead, cortical cells involved in learning a spatial memory task subsequently formed cell assemblies during delta waves in response to transient reactivation of hippocampal ensembles during ripples. This process occurred selectively during endogenous or induced memory consolidation. Thus, delta waves represent isolated cortical computations tightly related to ongoing information processing underlying memory consolidation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000491290000054 |
WOS关键词 | PREFRONTAL CORTEX ; HIPPOCAMPAL RIPPLES ; CELL ASSEMBLIES ; SLEEP ; REACTIVATION ; OSCILLATIONS ; ORGANIZATION ; PLASTICITY ; NETWORKS ; PATTERNS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202582 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Univ PSL, CNRS, INSERM, CIRB,Coll France, Paris, France |
推荐引用方式 GB/T 7714 | Todorova, Ralitsa,Zugaro, Michael. Isolated cortical computations during delta waves support memory consolidation[J]. SCIENCE,2019,366(6463):377-+. |
APA | Todorova, Ralitsa,&Zugaro, Michael.(2019).Isolated cortical computations during delta waves support memory consolidation.SCIENCE,366(6463),377-+. |
MLA | Todorova, Ralitsa,et al."Isolated cortical computations during delta waves support memory consolidation".SCIENCE 366.6463(2019):377-+. |
条目包含的文件 | 条目无相关文件。 |
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