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DOI | 10.1126/science.aax3710 |
Deconstructing the sources of genotype-phenotype associations in humans | |
Young, Alexander I.1,2; Benonisdottir, Stefania1; Przeworski, Molly3,4; Kong, Augustine1 | |
2019-09-27 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6460页码:1396-1400 |
文章类型 | Review |
语种 | 英语 |
国家 | England; USA |
英文摘要 | Efforts to link variation in the human genome to phenotypes have progressed at a tremendous pace in recent decades. Most human traits have been shown to be affected by a large number of genetic variants across the genome. To interpret these associations and to use them reliably-in particular for phenotypic prediction-a better understanding of the many sources of genotype-phenotype associations is necessary. We summarize the progress that has been made in this direction in humans, notably in decomposing direct and indirect genetic effects as well as population structure confounding. We discuss the natural next steps in data collection and methodology development, with a focus on what can be gained by analyzing genotype and phenotype data from close relatives. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000488838600036 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; MISSING HERITABILITY ; GENE ; VARIANTS ; IDENTIFICATION ; PREDICTION ; DISEASES ; BREAST |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202405 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat Discovery, Oxford, England; 2.Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England; 3.Columbia Univ, Dept Biol Sci, New York, NY 10027 USA; 4.Columbia Univ, Dept Syst Biol, New York, NY 10027 USA |
推荐引用方式 GB/T 7714 | Young, Alexander I.,Benonisdottir, Stefania,Przeworski, Molly,et al. Deconstructing the sources of genotype-phenotype associations in humans[J]. SCIENCE,2019,365(6460):1396-1400. |
APA | Young, Alexander I.,Benonisdottir, Stefania,Przeworski, Molly,&Kong, Augustine.(2019).Deconstructing the sources of genotype-phenotype associations in humans.SCIENCE,365(6460),1396-1400. |
MLA | Young, Alexander I.,et al."Deconstructing the sources of genotype-phenotype associations in humans".SCIENCE 365.6460(2019):1396-1400. |
条目包含的文件 | 条目无相关文件。 |
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