Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aax4588 |
Translational genomics and precision medicine: Moving from the lab to the clinic | |
Zeggini, Eleftheria1; Gloyn, Anna L.2,3,4; Barton, Anne C.5,6; Wain, Louise V.7,8 | |
2019-09-27 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6460页码:1409-1413 |
文章类型 | Review |
语种 | 英语 |
国家 | Germany; England |
英文摘要 | Translational genomics aims to improve human health by building on discoveries made through genetics research and applying them in the clinical setting. This progress has been made possible by technological advances in genomics and analytics and by the digital revolution. Such advances should enable the development of prognostic markers, tailored interventions, and the design of prophylactic preventive approaches. We are at the cusp of predicting disease risk for some disorders by means of polygenic risk scores integrated with classical epidemiological risk factors. This should lead to better risk stratification and clinical decision-making. A deeper understanding of the link between genome-wide sequence and association with well-characterized phenotypes will empower the development of biomarkers to aid diagnosis, inform disease progression trajectories. and allow better targeting of treatments to those patients most likely to respond. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000488838600039 |
WOS关键词 | ASSOCIATION ; RISK ; GENETICS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202404 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Translat Genom, Neuherberg, Germany; 2.Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England; 3.Univ Oxford, Wellcome Ctr Human Genet, Oxford, England; 4.Churchill Hosp, Oxford NIHR Biomed Res Ctr, Oxford, England; 5.Univ Manchester, Manchester Acad Hlth Sci Ctr, Ctr Musculoskeletal Res, Versus Arthrit Ctr Genet & Genom, Manchester, Lancs, England; 6.Manchester Univ NHS Fdn Trust, NIHR Manchester Biomed Res Ctr, Manchester, Lancs, England; 7.Univ Leicester, Dept Hlth Sci, Leicester, Leics, England; 8.Glenfield Hosp, Leicester Resp Biomed Res Ctr, Natl Inst Hlth Res, Leicester, Leics, England |
推荐引用方式 GB/T 7714 | Zeggini, Eleftheria,Gloyn, Anna L.,Barton, Anne C.,et al. Translational genomics and precision medicine: Moving from the lab to the clinic[J]. SCIENCE,2019,365(6460):1409-1413. |
APA | Zeggini, Eleftheria,Gloyn, Anna L.,Barton, Anne C.,&Wain, Louise V..(2019).Translational genomics and precision medicine: Moving from the lab to the clinic.SCIENCE,365(6460),1409-1413. |
MLA | Zeggini, Eleftheria,et al."Translational genomics and precision medicine: Moving from the lab to the clinic".SCIENCE 365.6460(2019):1409-1413. |
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