GSTDTAP  > 地球科学
DOI10.1126/science.aax6648
Mapping human cell phenotypes to genotypes with single-cell genomics
Camp, J. Gray1; Platt, Randall2; Treutlein, Barbara2
2019-09-27
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号365期号:6460页码:1401-+
文章类型Review
语种英语
国家Switzerland
英文摘要

The cumulative activity of all of the body's cells, with their myriad interactions, life histories. and environmental experiences, gives rise to a condition that is distinctly human and specific to each individual. It is an enduring goal to catalog our human cell types, to understand how they develop, how they vary between individuals, and how they fail in disease. Single-cell genomics has revolutionized this endeavor because sequencing-based methods provide a means to quantitatively annotate cell states on the basis of high-information content and high-throughput measurements. Together with advances in stem cell biology and gene editing, we are in the midst of a fascinating journey to understand the cellular phenotypes that compose human bodies and how the human genome is used to build and maintain each cell. Here, we will review recent advances into how single-cell genomics is being used to develop personalized phenotyping strategies that cross subcellular, cellular, and tissue scales to link our genome to our cumulative cellular phenotypes.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000488838600037
WOS关键词HUMAN STEM-CELL ; SELF-ORGANIZATION ; CRISPR ; ORGANOIDS ; SCREENS ; SEQ ; DNA ; TRANSCRIPTION ; TECHNOLOGIES ; GENERATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/202400
专题地球科学
资源环境科学
气候变化
作者单位1.Inst Mol & Clin Ophthalmol Basel, Basel, Switzerland;
2.Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland
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GB/T 7714
Camp, J. Gray,Platt, Randall,Treutlein, Barbara. Mapping human cell phenotypes to genotypes with single-cell genomics[J]. SCIENCE,2019,365(6460):1401-+.
APA Camp, J. Gray,Platt, Randall,&Treutlein, Barbara.(2019).Mapping human cell phenotypes to genotypes with single-cell genomics.SCIENCE,365(6460),1401-+.
MLA Camp, J. Gray,et al."Mapping human cell phenotypes to genotypes with single-cell genomics".SCIENCE 365.6460(2019):1401-+.
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