Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw5822 |
Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal | |
Froy, H.1,2; Sparks, A. M.1,3; Watt, K.1; Sinclair, R.1; Bach, F.4; Pilkington, J. G.1; Pemberton, J. M.1; McNeilly, T. N.5; Nussey, D. H.1 | |
2019-09-20 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6459页码:1296-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Scotland; Norway; England |
英文摘要 | Our understanding of the deterioration in immune function in old age-immunosenescence-derives principally from studies of modern human populations and laboratory animals. The generality and significance of this process for systems experiencing complex, natural infections and environmental challenges are unknown. Here, we show that late-life declines in an important immune marker of resistance to helminth parasites in wild Soay sheep predict overwinter mortality. We found senescence in circulating antibody levels against a highly prevalent nematode worm, which was associated with reduced adult survival probability, independent of changes in body weight. These findings establish a role for immunosenescence in the ecology and evolution of natural populations. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000487547400044 |
WOS关键词 | OVIS-ARIES L ; NATURAL-SELECTION ; SHEEP ; AGE ; POPULATIONS ; RESISTANCE ; INFECTION ; PATTERNS ; TRAITS ; SEX |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202354 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Edinburgh, Inst Evolutionary Biol, Edinburgh, Midlothian, Scotland; 2.Norwegian Univ Sci & Technol, Ctr Biodivers Dynam, Trondheim, Norway; 3.Univ Leeds, Sch Biol, Fac Biol Sci, Leeds, W Yorkshire, England; 4.Univ Edinburgh, Inst Immunol & Infect Res, Edinburgh, Midlothian, Scotland; 5.Moredun Res Inst, Pentlands Sci Pk, Penicuik, Midlothian, Scotland |
推荐引用方式 GB/T 7714 | Froy, H.,Sparks, A. M.,Watt, K.,et al. Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal[J]. SCIENCE,2019,365(6459):1296-+. |
APA | Froy, H..,Sparks, A. M..,Watt, K..,Sinclair, R..,Bach, F..,...&Nussey, D. H..(2019).Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal.SCIENCE,365(6459),1296-+. |
MLA | Froy, H.,et al."Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal".SCIENCE 365.6459(2019):1296-+. |
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