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DOI | 10.1126/science.aav6695 |
Evaluation of an antibody to alpha(4)beta(7) in the control of SIVmac239-nef-stop infection | |
Di Mascio, M.1; Lifson, J. D.2; Srinivasula, S.3; Kim, I.4; DeGrange, P.5; Keele, B. F.2; Belli, A. J.6; Reimann, K. A.6; Wang, Y.8; Proschan, M.7; Lane, H. C.8; Fauci, A. S.8 | |
2019-09-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6457页码:1025-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Treatment of SIV-infected rhesus macaques with short-term antiretroviral therapy (ART) and partially overlapping infusions of antibody to integrin a 4 0 7 was reported to induce durable posttreatment viral suppression. In an attempt to replicate those observations, we treated macaques infected with the same virus and with the same ART and monoclonal antibody (mAb) regimens (anti-alpha(4)beta(7) versus control mAb). Sequencing demonstrated that the virus used was actually SlVmac239-nef-stop, not wild-type SIVmac239. A positive correlation was found at 2 weeks after infection between the frequency of repair of attenuated Nef-STOP virus to pathogenic Nef-OPEN and plasma SIV RNA levels. Levels of plasma viremia before the first antibody infusion and preinfection levels of alpha(4)beta(hi)(7) CD4(+) T cells, but not treatment with antibody to alpha(4)beta(7), correlated with levels of viral replication upon discontinuation of all treatments. Follow-up plasma viremia, peripheral blood CD4(+) T cell counts, and lymph node and rectal tissue viral load were not significantly different between anti-U4 17 and control mAb groups. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000484732700046 |
WOS关键词 | SIMIAN IMMUNODEFICIENCY VIRUS ; INTEGRIN ALPHA(4)BETA(7) ; MACAQUES ; DISCOVERY ; RECEPTOR ; SUBSETS ; DISEASE ; TISSUES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202251 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NIAID, Div Clin Res, AIDS Imaging Res Sect, NIH, Bethesda, MD 20892 USA; 2.Frederick Natl Lab, AIDS & Canc Virus Program, Frederick, MD 21702 USA; 3.Frederick Natl Lab Canc Res, Clin Monitoring Res Program Directorate, Frederick, MD 21702 USA; 4.Frederick Natl Lab Canc Res, Appl Dev Res Directorate, Frederick, MD 21702 USA; 5.NIAID Frederick, Battelle Charles River Integrated Res Facil, Frederick, MD 21702 USA; 6.Univ Massachusetts, Med Sch, MassBiol, Boston, MA 02126 USA; 7.NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20852 USA; 8.NIAID, Lab Immunoregulat, Div Intramural Res, NIH, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Di Mascio, M.,Lifson, J. D.,Srinivasula, S.,et al. Evaluation of an antibody to alpha(4)beta(7) in the control of SIVmac239-nef-stop infection[J]. SCIENCE,2019,365(6457):1025-+. |
APA | Di Mascio, M..,Lifson, J. D..,Srinivasula, S..,Kim, I..,DeGrange, P..,...&Fauci, A. S..(2019).Evaluation of an antibody to alpha(4)beta(7) in the control of SIVmac239-nef-stop infection.SCIENCE,365(6457),1025-+. |
MLA | Di Mascio, M.,et al."Evaluation of an antibody to alpha(4)beta(7) in the control of SIVmac239-nef-stop infection".SCIENCE 365.6457(2019):1025-+. |
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