Lack of therapeutic efficacy of an antibody to alpha(4)beta(7) SIVmac251-infected rhesus macaques

doi:10.1126/science.aaw8562

GSTDTAP > 地球科学

DOI	10.1126/science.aaw8562
	Lack of therapeutic efficacy of an antibody to alpha(4)beta(7) SIVmac251-infected rhesus macaques
	Abbink, Peter 1; Mercado, Noe B.1; Nkolola, Joseph P.1; Peterson, Rebecca L.1; Tuyishime, Hubert 1; McMahan, Katherine 1; Moseley, Edward T.1; Borducchi, Erica N.1; Chandrashekar, Abishek 1; Bondzie, Esther A.1; Agarwal, Arshi 1; Belli, Aaron J.2; Reimann, Keith A.2; Keele, Brandon F.3; Geleziunas, Romas 4; Lewis, Mark G.5; Barouch, Dan H.1,6
	2019-09-06
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	365 期号:6457 页码:1029-+
文章类型	Article
语种	英语
国家	USA
英文摘要	Sustained virologic control of human immunodeficiency virus type 1 (HIV-1) infection after discontinuation of antiretroviral therapy (ART) is a major goal of the HIV-1 cure field. A recent study reported that administration of an antibody against alpha(4)beta(7) induced durable virologic control after ART discontinuation in 100% of rhesus macaques infected with an attenuated strain of simian immunodeficiency virus (SIV) containing a stop codon in nef. We performed similar studies in 50 rhesus macaques infected with wild-type, pathogenic SIVmac251. In animals that initiated ARTduring either acute or chronic infection, anti-alpha(4)beta(7) antibody infusion had no detectable effect on the viral reservoir or viral rebound after ART discontinuation. These data demonstrate that anti-alpha(4)beta(7) antibody administration did not provide therapeutic efficacy in the model of pathogenic SIVmac251 infection of rhesus macaques.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000484732700047
WOS关键词	REPLICATION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/202246
专题	地球科学资源环境科学气候变化
作者单位	1.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA; 2.Univ Massachusetts, Med Sch, MassBiol, Boston, MA 02126 USA; 3.Frederick Natl Lab, AIDS & Canc Virus Program, Frederick, MD 21702 USA; 4.Gilead Sci, Foster City, CA 94404 USA; 5.Bioqual, Rockville, MD 20852 USA; 6.Ragon Inst Massachusetts Gen Hosp Massachusetts I, Cambridge, MA 02139 USA
推荐引用方式 GB/T 7714	Abbink, Peter,Mercado, Noe B.,Nkolola, Joseph P.,et al. Lack of therapeutic efficacy of an antibody to alpha(4)beta(7) SIVmac251-infected rhesus macaques[J]. SCIENCE,2019,365(6457):1029-+.
APA	Abbink, Peter.,Mercado, Noe B..,Nkolola, Joseph P..,Peterson, Rebecca L..,Tuyishime, Hubert.,...&Barouch, Dan H..(2019).Lack of therapeutic efficacy of an antibody to alpha(4)beta(7) SIVmac251-infected rhesus macaques.SCIENCE,365(6457),1029-+.
MLA	Abbink, Peter,et al."Lack of therapeutic efficacy of an antibody to alpha(4)beta(7) SIVmac251-infected rhesus macaques".SCIENCE 365.6457(2019):1029-+.