Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aax2685 |
Structure elucidation of colibactin and its DNA cross-links | |
Xue, Mengzhao1; Kim, Chung Sub1,2; Healy, Alan R.1,2,7; Wernke, Kevin M.1; Wang, Zhixun1,8; Frischling, Madeline C.1; Shine, Emilee E.2,3; Wang, Weiwei4,5; Herzon, Seth B.1,6; Crawford, Jason M.1,2,3 | |
2019-09-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6457页码:1000-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; U Arab Emirates |
英文摘要 | Colibactin is a complex secondary metabolite produced by some genotoxic gut Escherichia coli strains. The presence of colibactin-producing bacteria correlates with the frequency and severity of colorectal cancer in humans. However, because colibactin has not been isolated or structurally characterized, studying the physiological effects of colibactin-producing bacteria in the human gut has been difficult. We used a combination of genetics, isotope labeling, tandem mass spectrometry, and chemical synthesis to deduce the structure of colibactin. Our structural assignment accounts for all known biosynthetic and cell biology data and suggests roles for the final unaccounted enzymes in the colibactin gene cluster. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000484732700039 |
WOS关键词 | IN-VIVO ; BIOSYNTHESIS ; MECHANISM ; MODEL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202243 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA; 2.Yale Univ, Chem Biol Inst, West Haven, CT 06516 USA; 3.Yale Sch Med, Dept Microbial Pathogenesis, New Haven, CT 06536 USA; 4.Yale Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA; 5.Yale Sch Med, WM Keck Biotechnol Resource Lab, New Haven, CT 06510 USA; 6.Yale Sch Med, Dept Pharmacol, New Haven, CT 06520 USA; 7.New York Univ Abu Dhabi, POB 129188, Abu Dhabi, U Arab Emirates; 8.Merck, Dept Proc Res & Dev, Rahway, NJ 07065 USA |
推荐引用方式 GB/T 7714 | Xue, Mengzhao,Kim, Chung Sub,Healy, Alan R.,et al. Structure elucidation of colibactin and its DNA cross-links[J]. SCIENCE,2019,365(6457):1000-+. |
APA | Xue, Mengzhao.,Kim, Chung Sub.,Healy, Alan R..,Wernke, Kevin M..,Wang, Zhixun.,...&Crawford, Jason M..(2019).Structure elucidation of colibactin and its DNA cross-links.SCIENCE,365(6457),1000-+. |
MLA | Xue, Mengzhao,et al."Structure elucidation of colibactin and its DNA cross-links".SCIENCE 365.6457(2019):1000-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论