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DOI | 10.1126/science.aav8907 |
Rhizobial tRNA-derived small RNAs are signal molecules regulating plant nodulation | |
Ren, Bo1; Wang, Xutong1; Duan, Jingbo1; Ma, Jianxin1,2 | |
2019-08-30 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6456页码:919-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Rhizobial infection and root nodule formation in legumes require recognition of signal molecules produced by the bacteria and their hosts. Here, we show that rhizobial transfer RNA (tRNA)-derived small RNA fragments (tRFs) are signal molecules that modulate host nodulation. Three families of rhizobial tRFs were confirmed to regulate host genes associated with nodule initiation and development through hijacking the host RNA-interference machinery that involves ARGONAUTE 1. Silencing individual tRFs with the use of short tandem target mimics or by overexpressing their targets represses root hair curling and nodule formation, whereas repressing these targets with artificial microRNAs identical to the respective tRFs or mutating these targets with CRISPR-Cas9 promotes nodulation. Our findings thus uncover a bacterial small RNA-mediated mechanism for prokaryote-eukaryote interaction and may pave the way for enhancing nodulation efficiency in legumes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483975800046 |
WOS关键词 | EXPRESSION ; GENE ; SYSTEM ; CELL ; TOOL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202198 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA; 2.Purdue Univ, Ctr Plant Biol, W Lafayette, IN 47907 USA |
推荐引用方式 GB/T 7714 | Ren, Bo,Wang, Xutong,Duan, Jingbo,et al. Rhizobial tRNA-derived small RNAs are signal molecules regulating plant nodulation[J]. SCIENCE,2019,365(6456):919-+. |
APA | Ren, Bo,Wang, Xutong,Duan, Jingbo,&Ma, Jianxin.(2019).Rhizobial tRNA-derived small RNAs are signal molecules regulating plant nodulation.SCIENCE,365(6456),919-+. |
MLA | Ren, Bo,et al."Rhizobial tRNA-derived small RNAs are signal molecules regulating plant nodulation".SCIENCE 365.6456(2019):919-+. |
条目包含的文件 | 条目无相关文件。 |
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