Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav5427 |
Major subpopulations of Plasmodium falciparum in sub-Saharan Africa | |
Amambua-Ngwa, Alfred1; 39;Alessandro, Umberto2 | |
2019-08-23 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6455页码:813-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Gambia; Ghana; Kenya; USA; England; Ethiopia; Madagascar; Tanzania; Cameroon; Germany; Cote Ivoire; Gabon; Nigeria; Mali |
英文摘要 | Understanding genomic variation and population structure of Plasmodium falciparum across Africa is necessary to sustain progress toward malaria elimination. Genome clustering of 2263 P. falciparum isolates from 24 malaria-endemic settings in 15 African countries identified major western, central, and eastern ancestries, plus a highly divergent Ethiopian population. Ancestry aligned to these regional blocs, overlapping with both the parasite's origin and with historical human migration. The parasite populations are interbred and shared genomic haplotypes, especially across drug resistance loci, which showed the strongest recent identity-by-descent between populations. A recent signature of selection on chromosome 12 with candidate resistance loci against artemisinin derivatives was evident in Ghana and Malawi. Such selection and the emerging substructure may affect treatment-based intervention strategies against P. falciparum malaria. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000482464000052 |
WOS关键词 | POPULATION-STRUCTURE ; DIVERSITY ; EVOLUTION ; GENOME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202144 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.LSHTM, Med Res Council Unit Gambia, Banjul, Gambia; 2.Univ Ghana, WACCBIP, Accra, Ghana; 3.Kenya Govt Med Res Ctr, US Army Med Res Directorate Africa, Walter Reed Project, Kisumu, Kenya; 4.US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA; 5.Wellcome Sanger Inst, Hinxton, England; 6.Univ Oxford, Big Data Inst, MRC Ctr Genom & Global Hlth, Oxford, England; 7.NMIMR, Accra, Ghana; 8.Univ Addis Ababa, Aklilu Lemma Inst Pathobiol, Addis Ababa, Ethiopia; 9.Inst Pasteur Madagascar, Antananarivo, Madagascar; 10.NIMR, Tanga, Tanzania; 11.Univ Buea, Dept Biochem & Mol Biol, Buea, Cameroon; 12.BNITM, Hamburg, Germany; 13.Univ Felix Houphouet Boigny, Unite Sci Pharmaceut & Biol, Abidjan, Cote Ivoire; 14.Univ Hlth Sci, Fac Med, Libreville, Gabon; 15.Univ Lagos, Dept Zool, Lagos, Nigeria; 16.Univ Sci Techn & Technol Bamako, Malaria Res & Training Ctr, Bamako, Mali |
推荐引用方式 GB/T 7714 | Amambua-Ngwa, Alfred,39;Alessandro, Umberto. Major subpopulations of Plasmodium falciparum in sub-Saharan Africa[J]. SCIENCE,2019,365(6455):813-+. |
APA | Amambua-Ngwa, Alfred,&39;Alessandro, Umberto.(2019).Major subpopulations of Plasmodium falciparum in sub-Saharan Africa.SCIENCE,365(6455),813-+. |
MLA | Amambua-Ngwa, Alfred,et al."Major subpopulations of Plasmodium falciparum in sub-Saharan Africa".SCIENCE 365.6455(2019):813-+. |
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