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DOI | 10.1126/science.aax1911 |
NAD(+) cleavage activity by animal an plant TIR domains in cell death pathways | |
Horsefield, Shane1,2; Burdett, Hayden1,2; Zhang, Xiaoxiao3,4; Manik, Mohammad K.1,2; Shi, Yun5; Chen, Jian3,4; Qi, Tiancong6; Gilley, Jonathan7,8; Lai, Jhih-Siang1,2; Rank, Maxwell X.1,2; Casey, Lachlan W.1,2,9; Gu, Weixi1,2; Ericsson, Daniel J.10; Foley, Gabriel1,2; Hughes, Robert O.11; Bosanac, Todd11; von Itzstein, Mark5; Rathjen, John P.4; Nanson, Jeffrey D.1,2; Boden, Mikael1,2; Dry, Ian B.12; Williams, Simon J.4; Staskawicz, Brian J.; Coleman, Michael P.; Ve, Thomas1,2,5; Dodds, Peter N.3; Kobe, Bostjan1,2 | |
2019-08-23 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6455页码:793-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Australia; USA; England |
英文摘要 | SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD(+)) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related Toll/interleukin-1 receptor (TIR) domains in these proteins, which, as we show, feature self-association-dependent NAD(+) cleavage activity associated with cell death signaling. We further show that SARM1 SAM (sterile alpha motif) domains form an octamer essential for axon degeneration that contributes to TIR domain enzymatic activity. The crystal structures of ribose and NADP(+) (the oxidized form of nicotinamide adenine dinucleotide phosphate) complexes of SARM1 and plant NLR RUN1 TIR domains, respectively, reveal a conserved substrate binding site. NAD(+) cleavage by TIR domains is therefore a conserved feature of animal and plant cell death signaling pathways. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000482464000048 |
WOS关键词 | SMALL-ANGLE SCATTERING ; PARTICLE MESH EWALD ; RESISTANCE PROTEIN ; DISEASE RESISTANCE ; ASSEMBLY FORMATION ; ESCHERICHIA-COLI ; ACCURATE DOCKING ; SELF-ASSOCIATION ; STRUCTURAL BASIS ; INNATE IMMUNITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202134 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Queensland, Sch Chem & Mol Biosci, Inst Mol Biosci, Brisbane, Qld 4072, Australia; 2.Univ Queensland, Australian Infect Dis Res Ctr, Brisbane, Qld 4072, Australia; 3.Agr & Food Commonwealth Sci & Ind Res Org, Canberra, ACT 2601, Australia; 4.Australian Natl Univ, Res Sch Biol, Plant Sci Div, Canberra, ACT 2601, Australia; 5.Griffith Univ, Inst Glyc, Southport, Qld 4222, Australia; 6.Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA; 7.Univ Cambridge, Dept Clin Neurosci, John von Geest Ctr Brain Repair, ED Adrian Bldg,Robinson Way, Cambridge CB2 0PY, England; 8.Babraham Inst, Cambridge CB22 3AT, England; 9.Univ Queensland, Ctr Microscopy & Microanal, Brisbane, Qld 4072, Australia; 10.Beamlines Australian Synchrotron, Macromol Crystallog MX, Melbourne, Vic 3168, Australia; 11.Disarm Therapeut, 400 Technol Sq, Cambridge, MA 02139 USA; 12.Agr & Food Commonwealth Sci & Ind Res Org, Urrbrae, SA 5064, Australia |
推荐引用方式 GB/T 7714 | Horsefield, Shane,Burdett, Hayden,Zhang, Xiaoxiao,et al. NAD(+) cleavage activity by animal an plant TIR domains in cell death pathways[J]. SCIENCE,2019,365(6455):793-+. |
APA | Horsefield, Shane.,Burdett, Hayden.,Zhang, Xiaoxiao.,Manik, Mohammad K..,Shi, Yun.,...&Kobe, Bostjan.(2019).NAD(+) cleavage activity by animal an plant TIR domains in cell death pathways.SCIENCE,365(6455),793-+. |
MLA | Horsefield, Shane,et al."NAD(+) cleavage activity by animal an plant TIR domains in cell death pathways".SCIENCE 365.6455(2019):793-+. |
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