Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau3429 |
Active cell migration is critical for steady-state epithelial turnover in the gut | |
Krndija, Denis1; El Marjou, Fatima1; Guirao, Boris2; Richon, Sophie1; Leroy, Olivier2; Bellaiche, Yohanns2; Hannezo, Edouard3; Vignjevic, Danijela Matic1 | |
2019-08-16 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6454页码:705-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France; Austria |
英文摘要 | Steady-state turnover is a hallmark of epithelial tissues throughout adult life. Intestinal epithelial turnover is marked by continuous cell migration, which is assumed to be driven by mitotic pressure from the crypts. However, the balance of forces in renewal remains ill-defined. Combining biophysical modeling and quantitative three-dimensional tissue imaging with genetic and physical manipulations, we revealed the existence of an actin-related protein 2/3 complex-dependent active migratory force, which explains quantitatively the profiles of cell speed, density, and tissue tension along the villi. Cells migrate collectively with minimal rearrangements while displaying dual-apicobasal and front-back-polarity characterized by actin-rich basal protrusions oriented in the direction of migration. We propose that active migration is a critical component of gut epithelial turnover. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000481688700050 |
WOS关键词 | SMALL-INTESTINE ; ARP2/3 COMPLEX ; STEM-CELLS ; FORCE ; LAMELLIPODIA ; DIFFERENTIATION ; PROLIFERATION ; POLARITY ; RENEWAL ; CRYPTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202097 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.PSL Res Univ, Inst Curie, CNRS, UMR 144, F-75005 Paris, France; 2.PSL Res Univ, Inst Curie, U934, UMR3215, F-75005 Paris, France; 3.IST Austria, Campus 1, A-3400 Klosterneuburg, Austria |
推荐引用方式 GB/T 7714 | Krndija, Denis,El Marjou, Fatima,Guirao, Boris,et al. Active cell migration is critical for steady-state epithelial turnover in the gut[J]. SCIENCE,2019,365(6454):705-+. |
APA | Krndija, Denis.,El Marjou, Fatima.,Guirao, Boris.,Richon, Sophie.,Leroy, Olivier.,...&Vignjevic, Danijela Matic.(2019).Active cell migration is critical for steady-state epithelial turnover in the gut.SCIENCE,365(6454),705-+. |
MLA | Krndija, Denis,et al."Active cell migration is critical for steady-state epithelial turnover in the gut".SCIENCE 365.6454(2019):705-+. |
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