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DOI | 10.1126/science.aav0758 |
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses | |
Wang, Lei1,2,3; Wen, Mingyue2,3; Cao, Xuetao1,2,3,4,5 | |
2019-08-16 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6454页码:656-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | DNA viruses typically eject genomic DNA into the nuclei of host cells after entry. It is unclear, however, how nuclear pathogen-derived DNA triggers innate immune responses. We report that heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) recognizes pathogenic DNA and amplifies interferon-alpha/beta (IFN-alpha/beta) production. Upon DNA virus infection, nuclear-localized hnRNPA2B1 senses viral DNA, homodimerizes, and is then demethylated at arginine-226 by the arginine demethylase JMJD6. This results in hnRNPA2B1 translocation to the cytoplasm where it activates the TANK-binding kinase 1-interferon regulatory factor 3 (TBK1-IRF3) pathway, leading to IFN-alpha/beta production. Additionally, hnRNPA2B1 facilitates N-6-methyladenosine (m(6)A) modification and nucleocytoplasmic trafficking of CGAS, IFI16, and STING messenger RNAs. This, in turn, amplifies the activation of cytoplasmic TBK1-IRF3 mediated by these factors. Thus, hnRNPA2B1 plays important roles in initiating IFN-alpha/beta production and enhancing stimulator of interferon genes (STING)-dependent cytoplasmic antiviral signaling. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000481688700037 |
WOS关键词 | GMP-AMP SYNTHASE ; CYTOSOLIC DNA ; I INTERFERON ; SENSOR ; RNA ; RECOGNITION ; IFI16 ; INFLAMMASOME ; RECEPTORS ; DEFENSE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202096 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Nankai Univ, Coll Life Sci, Natl Key Lab Med Chem Biol, Tianjin 300071, Peoples R China; 2.Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China; 3.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China; 4.Chinese Acad Med Sci, Natl Key Lab Med Mol Biol, Beijing 100005, Peoples R China; 5.Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Dept Immunol, Beijing 100005, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Lei,Wen, Mingyue,Cao, Xuetao. Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses[J]. SCIENCE,2019,365(6454):656-+. |
APA | Wang, Lei,Wen, Mingyue,&Cao, Xuetao.(2019).Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.SCIENCE,365(6454),656-+. |
MLA | Wang, Lei,et al."Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses".SCIENCE 365.6454(2019):656-+. |
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