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DOI | 10.1126/science.aax6452 |
Specialized cutaneous Schwann cells initiate pain sensation | |
Abdo, Hind1; Calvo-Enrique, Laura1; Lopez, Jose Martinez1; Song, Jianren2; Zhang, Ming-Dong1; Usoskin, Dmitry1; El Manira, Abdeljabbar2; Adameyko, Igor3; Hjerling-Leffler, Jens1; Ernfors, Patrik1 | |
2019-08-16 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6454页码:695-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden |
英文摘要 | An essential prerequisite for the survival of an organism is the ability to detect and respond to aversive stimuli. Current belief is that noxious stimuli directly activate nociceptive sensory nerve endings in the skin. We discovered a specialized cutaneous glial cell type with extensive processes forming a mesh-like network in the subepidermal border of the skin that conveys noxious thermal and mechanical sensitivity. We demonstrate a direct excitatory functional connection to sensory neurons and provide evidence of a previously unknown organ that has an essential physiological role in sensing noxious stimuli. Thus, these glial cells, which are intimately associated with unmyelinated nociceptive nerves, are inherently mechanosensitive and transmit nociceptive information to the nerve. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000481688700048 |
WOS关键词 | NEUROPATHIC PAIN ; MERKEL CELLS ; TRP CHANNEL ; RECEPTOR ; STIMULI ; SENSITIVITY ; NEURONS ; PIEZO2 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202081 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Karolinska Inst, Div Mol Neurobiol, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden; 2.Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden; 3.Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Abdo, Hind,Calvo-Enrique, Laura,Lopez, Jose Martinez,et al. Specialized cutaneous Schwann cells initiate pain sensation[J]. SCIENCE,2019,365(6454):695-+. |
APA | Abdo, Hind.,Calvo-Enrique, Laura.,Lopez, Jose Martinez.,Song, Jianren.,Zhang, Ming-Dong.,...&Ernfors, Patrik.(2019).Specialized cutaneous Schwann cells initiate pain sensation.SCIENCE,365(6454),695-+. |
MLA | Abdo, Hind,et al."Specialized cutaneous Schwann cells initiate pain sensation".SCIENCE 365.6454(2019):695-+. |
条目包含的文件 | 条目无相关文件。 |
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